Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity
We have developed novel composites by grafting caffeic acid (CA) onto the P(3HB)-EC based material and laccase from Trametes versicolor was used for grafting purposes. The resulting composites were designated as CA-g-P(3HB)-EC i.e., P(3HB)-EC (control), 5CA-g-P(3HB)-EC, 10CA-g-P(3HB)-EC, 15CA-g-P(3H...
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| Format: | Article |
| Language: | English |
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Budapest University of Technology and Economics
2015-09-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0006037&mi=cd |
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| author | H. M. N. Iqbal G. Kyazze I. C. Locke T. Tron T. Keshavarz |
| author_facet | H. M. N. Iqbal G. Kyazze I. C. Locke T. Tron T. Keshavarz |
| author_sort | H. M. N. Iqbal |
| collection | DOAJ |
| description | We have developed novel composites by grafting caffeic acid (CA) onto the P(3HB)-EC based material and laccase from Trametes versicolor was used for grafting purposes. The resulting composites were designated as CA-g-P(3HB)-EC i.e., P(3HB)-EC (control), 5CA-g-P(3HB)-EC, 10CA-g-P(3HB)-EC, 15CA-g-P(3HB)-EC and 20CA-g-P(3HB)-EC. FT-IR (Fourier-transform infrared spectroscopy) was used to examine the functional and elemental groups of the control and laccase-assisted graft composites. Evidently, 15CA-g-P(3HB)-EC composite exhibited resilient antibacterial activity against Gram-positive and Gram-negative bacterial strains. Moreover, a significant level of biocompatibility and biodegradability of the CA-g-P(3HB)-EC composites was also achieved with the human keratinocytes-like HaCaT cells and soil burial evaluation, respectively. In conclusion, the newly developed novel composites with multi characteristics could well represent the new wave of biomaterials for medical applications, and more specifically have promising future in the infection free would dressings, burn and/or skin regeneration field due to their sophisticated characteristics. |
| format | Article |
| id | doaj-art-35a95a1518a341d7b6d4c68b1452299d |
| institution | OA Journals |
| issn | 1788-618X |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-35a95a1518a341d7b6d4c68b1452299d2025-08-20T02:37:32ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2015-09-019976477210.3144/expresspolymlett.2015.72Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entityH. M. N. IqbalG. KyazzeI. C. LockeT. TronT. KeshavarzWe have developed novel composites by grafting caffeic acid (CA) onto the P(3HB)-EC based material and laccase from Trametes versicolor was used for grafting purposes. The resulting composites were designated as CA-g-P(3HB)-EC i.e., P(3HB)-EC (control), 5CA-g-P(3HB)-EC, 10CA-g-P(3HB)-EC, 15CA-g-P(3HB)-EC and 20CA-g-P(3HB)-EC. FT-IR (Fourier-transform infrared spectroscopy) was used to examine the functional and elemental groups of the control and laccase-assisted graft composites. Evidently, 15CA-g-P(3HB)-EC composite exhibited resilient antibacterial activity against Gram-positive and Gram-negative bacterial strains. Moreover, a significant level of biocompatibility and biodegradability of the CA-g-P(3HB)-EC composites was also achieved with the human keratinocytes-like HaCaT cells and soil burial evaluation, respectively. In conclusion, the newly developed novel composites with multi characteristics could well represent the new wave of biomaterials for medical applications, and more specifically have promising future in the infection free would dressings, burn and/or skin regeneration field due to their sophisticated characteristics.http://www.expresspolymlett.com/letolt.php?file=EPL-0006037&mi=cdPolymer compositesEnzymatic graftingLaccaseBiocompatible Biodegradable |
| spellingShingle | H. M. N. Iqbal G. Kyazze I. C. Locke T. Tron T. Keshavarz Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity eXPRESS Polymer Letters Polymer composites Enzymatic grafting Laccase Biocompatible Biodegradable |
| title | Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity |
| title_full | Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity |
| title_fullStr | Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity |
| title_full_unstemmed | Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity |
| title_short | Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity |
| title_sort | development of novel antibacterial active hacat biocompatible and biodegradable ca g p 3hb ec biocomposites with caffeic acid as a functional entity |
| topic | Polymer composites Enzymatic grafting Laccase Biocompatible Biodegradable |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0006037&mi=cd |
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