Enhancing Cancer Vaccine Efficacy: Backbone Modification with β‑Amino Acids Alters the Stability and Immunogenicity of MUC1-Derived Glycopeptide Formulations

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Main Authors: Ruslan Gibadullin, Óscar Suárez, Foivos S. Lazaris, Naiara Gutiez, Estibaliz Atondo, Sarai Araujo-Aris, Ander Eguskiza, Jiani Niu, Ariel J. Kuhn, Ana S. Grosso, Héctor Rodriguez, Fayna García-Martín, Filipa Marcelo, Tanausú Santos, Alberto Avenoza, Jesús H. Busto, Jesús M. Peregrina, Samuel H. Gellman, Juan Anguita, Roberto Fiammengo, Francisco Corzana
Format: Article
Language:English
Published: American Chemical Society 2025-05-01
Series:JACS Au
Online Access:https://doi.org/10.1021/jacsau.5c00224
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author Ruslan Gibadullin
Óscar Suárez
Foivos S. Lazaris
Naiara Gutiez
Estibaliz Atondo
Sarai Araujo-Aris
Ander Eguskiza
Jiani Niu
Ariel J. Kuhn
Ana S. Grosso
Héctor Rodriguez
Fayna García-Martín
Filipa Marcelo
Tanausú Santos
Alberto Avenoza
Jesús H. Busto
Jesús M. Peregrina
Samuel H. Gellman
Juan Anguita
Roberto Fiammengo
Francisco Corzana
author_facet Ruslan Gibadullin
Óscar Suárez
Foivos S. Lazaris
Naiara Gutiez
Estibaliz Atondo
Sarai Araujo-Aris
Ander Eguskiza
Jiani Niu
Ariel J. Kuhn
Ana S. Grosso
Héctor Rodriguez
Fayna García-Martín
Filipa Marcelo
Tanausú Santos
Alberto Avenoza
Jesús H. Busto
Jesús M. Peregrina
Samuel H. Gellman
Juan Anguita
Roberto Fiammengo
Francisco Corzana
author_sort Ruslan Gibadullin
collection DOAJ
format Article
id doaj-art-35a8461cda8e4cfa81502dcf46261344
institution Kabale University
issn 2691-3704
language English
publishDate 2025-05-01
publisher American Chemical Society
record_format Article
series JACS Au
spelling doaj-art-35a8461cda8e4cfa81502dcf462613442025-08-20T03:48:26ZengAmerican Chemical SocietyJACS Au2691-37042025-05-01552270228410.1021/jacsau.5c00224Enhancing Cancer Vaccine Efficacy: Backbone Modification with β‑Amino Acids Alters the Stability and Immunogenicity of MUC1-Derived Glycopeptide FormulationsRuslan Gibadullin0Óscar Suárez1Foivos S. Lazaris2Naiara Gutiez3Estibaliz Atondo4Sarai Araujo-Aris5Ander Eguskiza6Jiani Niu7Ariel J. Kuhn8Ana S. Grosso9Héctor Rodriguez10Fayna García-Martín11Filipa Marcelo12Tanausú Santos13Alberto Avenoza14Jesús H. Busto15Jesús M. Peregrina16Samuel H. Gellman17Juan Anguita18Roberto Fiammengo19Francisco Corzana20Department of Chemistry, University of Wisconsin, Madison, Wisconsin, United StatesDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, SpainDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, SpainInflammation and Macrophage Plasticity Laboratory, CIC BioGUNE, BRTA, Derio, SpainInflammation and Macrophage Plasticity Laboratory, CIC BioGUNE, BRTA, Derio, SpainInflammation and Macrophage Plasticity Laboratory, CIC BioGUNE, BRTA, Derio, SpainDepartment of Biotechnology, University of Verona, Verona, ItalyDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin, United StatesDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin, United StatesUCIBIO - Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Caparica, PortugalInflammation and Macrophage Plasticity Laboratory, CIC BioGUNE, BRTA, Derio, SpainDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, SpainUCIBIO - Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Caparica, PortugalDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, SpainDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, SpainDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, SpainDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, SpainDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin, United StatesInflammation and Macrophage Plasticity Laboratory, CIC BioGUNE, BRTA, Derio, SpainDepartment of Biotechnology, University of Verona, Verona, ItalyDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, Spainhttps://doi.org/10.1021/jacsau.5c00224
spellingShingle Ruslan Gibadullin
Óscar Suárez
Foivos S. Lazaris
Naiara Gutiez
Estibaliz Atondo
Sarai Araujo-Aris
Ander Eguskiza
Jiani Niu
Ariel J. Kuhn
Ana S. Grosso
Héctor Rodriguez
Fayna García-Martín
Filipa Marcelo
Tanausú Santos
Alberto Avenoza
Jesús H. Busto
Jesús M. Peregrina
Samuel H. Gellman
Juan Anguita
Roberto Fiammengo
Francisco Corzana
Enhancing Cancer Vaccine Efficacy: Backbone Modification with β‑Amino Acids Alters the Stability and Immunogenicity of MUC1-Derived Glycopeptide Formulations
JACS Au
title Enhancing Cancer Vaccine Efficacy: Backbone Modification with β‑Amino Acids Alters the Stability and Immunogenicity of MUC1-Derived Glycopeptide Formulations
title_full Enhancing Cancer Vaccine Efficacy: Backbone Modification with β‑Amino Acids Alters the Stability and Immunogenicity of MUC1-Derived Glycopeptide Formulations
title_fullStr Enhancing Cancer Vaccine Efficacy: Backbone Modification with β‑Amino Acids Alters the Stability and Immunogenicity of MUC1-Derived Glycopeptide Formulations
title_full_unstemmed Enhancing Cancer Vaccine Efficacy: Backbone Modification with β‑Amino Acids Alters the Stability and Immunogenicity of MUC1-Derived Glycopeptide Formulations
title_short Enhancing Cancer Vaccine Efficacy: Backbone Modification with β‑Amino Acids Alters the Stability and Immunogenicity of MUC1-Derived Glycopeptide Formulations
title_sort enhancing cancer vaccine efficacy backbone modification with β amino acids alters the stability and immunogenicity of muc1 derived glycopeptide formulations
url https://doi.org/10.1021/jacsau.5c00224
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