Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats
Background: Diabetes mellitus is the most common endocrine disease globally. Hyperglycemia in diabetes mellitus is known to trigger oxidative stress. The activity of glutathione peroxidase (GSH-Px) is decreased in diabetic conditions. Catalase activity acts as a defense system to prevent the format...
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| Format: | Article |
| Language: | English |
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Indonesian Society for Biochemistry and Molecular Biology
2023-12-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/137 |
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| author | Ariani Zaltin Okvenda Eti Yerizel Raveinal |
| author_facet | Ariani Zaltin Okvenda Eti Yerizel Raveinal |
| author_sort | Ariani Zaltin Okvenda |
| collection | DOAJ |
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Background: Diabetes mellitus is the most common endocrine disease globally. Hyperglycemia in diabetes mellitus is known to trigger oxidative stress. The activity of glutathione peroxidase (GSH-Px) is decreased in diabetic conditions. Catalase activity acts as a defense system to prevent the formation of free radicals (oxidants) in the human body.
Objective: This study aimed to determine the effectiveness of olive oil antioxidants on catalase activity and GSH-Px levels in hyperglycemic rats.
Methods: Adult male Wistar rats were randomized into three groups (n: 8): untreated control (Control), alloxan-induced untreated (Alloxan), and alloxan-induced treatment (Treatment) of olive oil at 25 mL/day for 14 days. Catalase activities were measured using the spectrophotometry method, and GSH-Px levels were analyzed using an enzyme-linked immunosorbent assay (ELISA).
Results: Administration of olive oil increased catalase activity compared to the untreated group in alloxan-induced rats. The average level of glutathione peroxidase was higher in the treatment group than in alloxan-induced rats.
Conclusion: Antioxidants in olive oil increased catalase activity and glutathione peroxidase levels in alloxan-induced hyperglycemic rats.
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| format | Article |
| id | doaj-art-35a564aa1238416ca2e905a96f2a5369 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-35a564aa1238416ca2e905a96f2a53692025-02-08T03:05:52ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222023-12-016210.32889/actabioina.137Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic ratsAriani Zaltin Okvenda0Eti Yerizel1Raveinal2Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Andalas, Padang, West Sumatera, IndonesiaDepartment of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang, West Sumatera, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, West Sumatera, Indonesia Background: Diabetes mellitus is the most common endocrine disease globally. Hyperglycemia in diabetes mellitus is known to trigger oxidative stress. The activity of glutathione peroxidase (GSH-Px) is decreased in diabetic conditions. Catalase activity acts as a defense system to prevent the formation of free radicals (oxidants) in the human body. Objective: This study aimed to determine the effectiveness of olive oil antioxidants on catalase activity and GSH-Px levels in hyperglycemic rats. Methods: Adult male Wistar rats were randomized into three groups (n: 8): untreated control (Control), alloxan-induced untreated (Alloxan), and alloxan-induced treatment (Treatment) of olive oil at 25 mL/day for 14 days. Catalase activities were measured using the spectrophotometry method, and GSH-Px levels were analyzed using an enzyme-linked immunosorbent assay (ELISA). Results: Administration of olive oil increased catalase activity compared to the untreated group in alloxan-induced rats. The average level of glutathione peroxidase was higher in the treatment group than in alloxan-induced rats. Conclusion: Antioxidants in olive oil increased catalase activity and glutathione peroxidase levels in alloxan-induced hyperglycemic rats. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/137Catalase ActivityGlutathione PeroxidaseHyperglycemicOlive OilOxidants |
| spellingShingle | Ariani Zaltin Okvenda Eti Yerizel Raveinal Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats Acta Biochimica Indonesiana Catalase Activity Glutathione Peroxidase Hyperglycemic Olive Oil Oxidants |
| title | Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats |
| title_full | Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats |
| title_fullStr | Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats |
| title_full_unstemmed | Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats |
| title_short | Olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats |
| title_sort | olive oil increase catalase activity and gluthatione peroxidase level in hyperglycemic rats |
| topic | Catalase Activity Glutathione Peroxidase Hyperglycemic Olive Oil Oxidants |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/137 |
| work_keys_str_mv | AT arianizaltinokvenda oliveoilincreasecatalaseactivityandgluthationeperoxidaselevelinhyperglycemicrats AT etiyerizel oliveoilincreasecatalaseactivityandgluthationeperoxidaselevelinhyperglycemicrats AT raveinal oliveoilincreasecatalaseactivityandgluthationeperoxidaselevelinhyperglycemicrats |