Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors
Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARγ and α, resulting in improved insulin re...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/581348 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545704390688768 |
|---|---|
| author | Xiaoyan Sheng Yuebo Zhang Zhenwei Gong Cheng Huang Ying Qin Zang |
| author_facet | Xiaoyan Sheng Yuebo Zhang Zhenwei Gong Cheng Huang Ying Qin Zang |
| author_sort | Xiaoyan Sheng |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARγ and α, resulting in improved insulin resistance, reduced fasted glucose, FFA, LDL-c, and AST levels in high-caloric diet-induced obesity (DIO) and db/db mice in its water extract form. In vitro studies demonstrate that cinnamon increases the expression of peroxisome proliferator-activated receptors γ and α (PPARγ/α) and their target genes such as LPL, CD36, GLUT4, and ACO in 3T3-L1 adipocyte. The transactivities of both full length and ligand-binding domain (LBD) of PPARγ and PPARα are activated by cinnamon as evidenced by reporter gene assays. These data suggest that cinnamon in its water extract form can act as a dual activator of PPARγ and α, and may be an alternative to PPARγ activator in managing obesity-related diabetes and hyperlipidemia. |
| format | Article |
| id | doaj-art-35a380ef161a48f3bb55df7faffb5464 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-35a380ef161a48f3bb55df7faffb54642025-02-03T07:24:56ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/581348581348Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated ReceptorsXiaoyan Sheng0Yuebo Zhang1Zhenwei Gong2Cheng Huang3Ying Qin Zang4Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, ChinaKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, ChinaPeroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARγ and α, resulting in improved insulin resistance, reduced fasted glucose, FFA, LDL-c, and AST levels in high-caloric diet-induced obesity (DIO) and db/db mice in its water extract form. In vitro studies demonstrate that cinnamon increases the expression of peroxisome proliferator-activated receptors γ and α (PPARγ/α) and their target genes such as LPL, CD36, GLUT4, and ACO in 3T3-L1 adipocyte. The transactivities of both full length and ligand-binding domain (LBD) of PPARγ and PPARα are activated by cinnamon as evidenced by reporter gene assays. These data suggest that cinnamon in its water extract form can act as a dual activator of PPARγ and α, and may be an alternative to PPARγ activator in managing obesity-related diabetes and hyperlipidemia.http://dx.doi.org/10.1155/2008/581348 |
| spellingShingle | Xiaoyan Sheng Yuebo Zhang Zhenwei Gong Cheng Huang Ying Qin Zang Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors PPAR Research |
| title | Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors |
| title_full | Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors |
| title_fullStr | Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors |
| title_full_unstemmed | Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors |
| title_short | Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors |
| title_sort | improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator activated receptors |
| url | http://dx.doi.org/10.1155/2008/581348 |
| work_keys_str_mv | AT xiaoyansheng improvedinsulinresistanceandlipidmetabolismbycinnamonextractthroughactivationofperoxisomeproliferatoractivatedreceptors AT yuebozhang improvedinsulinresistanceandlipidmetabolismbycinnamonextractthroughactivationofperoxisomeproliferatoractivatedreceptors AT zhenweigong improvedinsulinresistanceandlipidmetabolismbycinnamonextractthroughactivationofperoxisomeproliferatoractivatedreceptors AT chenghuang improvedinsulinresistanceandlipidmetabolismbycinnamonextractthroughactivationofperoxisomeproliferatoractivatedreceptors AT yingqinzang improvedinsulinresistanceandlipidmetabolismbycinnamonextractthroughactivationofperoxisomeproliferatoractivatedreceptors |