Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes.

Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes.

<h4>Background</h4>Intratumoral heterogeneity may help drive resistance to targeted therapies in cancer. In breast cancer, the presence of nodal metastases is a key indicator of poorer overall survival. The aim of this study was to identify somatic genetic alterations in early disseminat...

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Bibliographic Details
Main Authors: Kevin Blighe, Laura Kenny, Naina Patel, David S Guttery, Karen Page, Julian H Gronau, Cyrus Golshani, Justin Stebbing, R Charles Coombes, Jacqueline A Shaw
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0115346
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