Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity?
Background. Portal hypertension is a serious complication of liver cirrhosis. Objective. To identify relevant endoscopic findings in patients with advanced cirrhosis and consecutive portal hypertension. Methods. This was a retrospective study of liver transplant candidates who underwent upper gastro...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/2182784 |
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| author | David Kara Anna Hüsing-Kabar Hartmut Schmidt Inga Grünewald Gursimran Chandhok Miriam Maschmeier Iyad Kabar |
| author_facet | David Kara Anna Hüsing-Kabar Hartmut Schmidt Inga Grünewald Gursimran Chandhok Miriam Maschmeier Iyad Kabar |
| author_sort | David Kara |
| collection | DOAJ |
| description | Background. Portal hypertension is a serious complication of liver cirrhosis. Objective. To identify relevant endoscopic findings in patients with advanced cirrhosis and consecutive portal hypertension. Methods. This was a retrospective study of liver transplant candidates who underwent upper gastrointestinal endoscopy between April 2011 and November 2015. Results. A total of 1,045 upper endoscopies were analyzed. Portal hypertensive gastric and duodenal polyps were frequently observed and were associated with thrombocytopenia (p = 0.040; OR: 2.4, 95% CI 1.04–5.50), Child-Pugh score > 6 (p = 0.033; OR: 2.3, 95% CI 1.07–4.92), Model for End Stage Liver Disease score > 16 (p = 0.030; OR: 4.1, 95% CI 1.14–15.00), and previous rubber band ligation (p < 0.001; OR = 5.2, 95% CI 2.5–10.7). These polyps often recurred after polypectomy; however, no malignant transformation occurred during the observational time until October 2017. The most common endoscopic finding was esophageal varices, observed in more than 90% of patients. Conclusion. Portal hypertensive polyposis is common in patients with advanced cirrhosis. Our data suggest that these polyps have benign characteristics. |
| format | Article |
| id | doaj-art-359c67848e9047da90c9469e4ba08ebf |
| institution | OA Journals |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-359c67848e9047da90c9469e4ba08ebf2025-08-20T02:24:08ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/21827842182784Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity?David Kara0Anna Hüsing-Kabar1Hartmut Schmidt2Inga Grünewald3Gursimran Chandhok4Miriam Maschmeier5Iyad Kabar6Department of Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyUniversity Hospital Muenster, Gerhard-Domagk-Institute of Pathology, 48149 Muenster, GermanyDepartment of Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyBackground. Portal hypertension is a serious complication of liver cirrhosis. Objective. To identify relevant endoscopic findings in patients with advanced cirrhosis and consecutive portal hypertension. Methods. This was a retrospective study of liver transplant candidates who underwent upper gastrointestinal endoscopy between April 2011 and November 2015. Results. A total of 1,045 upper endoscopies were analyzed. Portal hypertensive gastric and duodenal polyps were frequently observed and were associated with thrombocytopenia (p = 0.040; OR: 2.4, 95% CI 1.04–5.50), Child-Pugh score > 6 (p = 0.033; OR: 2.3, 95% CI 1.07–4.92), Model for End Stage Liver Disease score > 16 (p = 0.030; OR: 4.1, 95% CI 1.14–15.00), and previous rubber band ligation (p < 0.001; OR = 5.2, 95% CI 2.5–10.7). These polyps often recurred after polypectomy; however, no malignant transformation occurred during the observational time until October 2017. The most common endoscopic finding was esophageal varices, observed in more than 90% of patients. Conclusion. Portal hypertensive polyposis is common in patients with advanced cirrhosis. Our data suggest that these polyps have benign characteristics.http://dx.doi.org/10.1155/2018/2182784 |
| spellingShingle | David Kara Anna Hüsing-Kabar Hartmut Schmidt Inga Grünewald Gursimran Chandhok Miriam Maschmeier Iyad Kabar Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity? Canadian Journal of Gastroenterology and Hepatology |
| title | Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity? |
| title_full | Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity? |
| title_fullStr | Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity? |
| title_full_unstemmed | Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity? |
| title_short | Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity? |
| title_sort | portal hypertensive polyposis in advanced liver cirrhosis the unknown entity |
| url | http://dx.doi.org/10.1155/2018/2182784 |
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