The lactate metabolism and protein lactylation in epilepsy
Protein lactylation is a new form of post-translational modification that has recently been proposed. Lactoyl groups, derived mainly from the glycolytic product lactate, have been linked to protein lactylation in brain tissue, which has been shown to correlate with increased neuronal excitability. I...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1464169/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841540101794955264 |
|---|---|
| author | Xi Kuang Shuang Chen Qingmei Ye |
| author_facet | Xi Kuang Shuang Chen Qingmei Ye |
| author_sort | Xi Kuang |
| collection | DOAJ |
| description | Protein lactylation is a new form of post-translational modification that has recently been proposed. Lactoyl groups, derived mainly from the glycolytic product lactate, have been linked to protein lactylation in brain tissue, which has been shown to correlate with increased neuronal excitability. Ischemic stroke may promote neuronal glycolysis, leading to lactate accumulation in brain tissue. This accumulation of lactate accumulation may heighten neuronal excitability by upregulating protein lactylation levels, potentially triggering post-stroke epilepsy. Although current clinical treatments for seizures have advanced significantly, approximately 30% of patients with epilepsy remain unresponsive to medication, and the prevalence of epilepsy continues to rise. This study explores the mechanisms of epilepsy-associated neuronal death mediated by lactate metabolism and protein lactylation. This study also examines the potential for histone deacetylase inhibitors to alleviate seizures by modifying lactylation levels, thereby offering fresh perspectives for future research into the pathogenesis and clinical treatment of epilepsy. |
| format | Article |
| id | doaj-art-3597d4b76aaa47e393433225b65baea9 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-3597d4b76aaa47e393433225b65baea92025-01-14T06:10:39ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-01-011810.3389/fncel.2024.14641691464169The lactate metabolism and protein lactylation in epilepsyXi Kuang0Shuang Chen1Qingmei Ye2Hainan Health Vocational College, Haikou, ChinaDepartment of Neurology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Hubei University of Chinese Medicine, Wuhan, ChinaHainan General Hospital and Hainan Affiliated Hospital of Hainan Medical University, Haikou, ChinaProtein lactylation is a new form of post-translational modification that has recently been proposed. Lactoyl groups, derived mainly from the glycolytic product lactate, have been linked to protein lactylation in brain tissue, which has been shown to correlate with increased neuronal excitability. Ischemic stroke may promote neuronal glycolysis, leading to lactate accumulation in brain tissue. This accumulation of lactate accumulation may heighten neuronal excitability by upregulating protein lactylation levels, potentially triggering post-stroke epilepsy. Although current clinical treatments for seizures have advanced significantly, approximately 30% of patients with epilepsy remain unresponsive to medication, and the prevalence of epilepsy continues to rise. This study explores the mechanisms of epilepsy-associated neuronal death mediated by lactate metabolism and protein lactylation. This study also examines the potential for histone deacetylase inhibitors to alleviate seizures by modifying lactylation levels, thereby offering fresh perspectives for future research into the pathogenesis and clinical treatment of epilepsy.https://www.frontiersin.org/articles/10.3389/fncel.2024.1464169/fullprotein lactylationhistone deacetylaseepilepsyhigh-mobility group box 1hypoxia-inducible factor-1αlactate |
| spellingShingle | Xi Kuang Shuang Chen Qingmei Ye The lactate metabolism and protein lactylation in epilepsy Frontiers in Cellular Neuroscience protein lactylation histone deacetylase epilepsy high-mobility group box 1 hypoxia-inducible factor-1α lactate |
| title | The lactate metabolism and protein lactylation in epilepsy |
| title_full | The lactate metabolism and protein lactylation in epilepsy |
| title_fullStr | The lactate metabolism and protein lactylation in epilepsy |
| title_full_unstemmed | The lactate metabolism and protein lactylation in epilepsy |
| title_short | The lactate metabolism and protein lactylation in epilepsy |
| title_sort | lactate metabolism and protein lactylation in epilepsy |
| topic | protein lactylation histone deacetylase epilepsy high-mobility group box 1 hypoxia-inducible factor-1α lactate |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1464169/full |
| work_keys_str_mv | AT xikuang thelactatemetabolismandproteinlactylationinepilepsy AT shuangchen thelactatemetabolismandproteinlactylationinepilepsy AT qingmeiye thelactatemetabolismandproteinlactylationinepilepsy AT xikuang lactatemetabolismandproteinlactylationinepilepsy AT shuangchen lactatemetabolismandproteinlactylationinepilepsy AT qingmeiye lactatemetabolismandproteinlactylationinepilepsy |