Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia
Introduction: Infiltrative anesthesia with lidocaine plays a vital role in pain management during dermatologic procedures, ensuring patient comfort throughout the process. Objective: We aimed to investigate the correlation between three different concentrations of lidocaine (2% lidocaine with 1:1...
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Mattioli1885
2025-07-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/5382 |
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| author | Van Thanh Le Thai Tri Thong Nguyen Quoc Hung Ta Anh Tuan Ngo Thanh Yen Thai Thanh Yen Phuong Thao Nguyen Vi Anh Le Ngoc Khanh Nam Tran Hanh Vy Tran |
| author_facet | Van Thanh Le Thai Tri Thong Nguyen Quoc Hung Ta Anh Tuan Ngo Thanh Yen Thai Thanh Yen Phuong Thao Nguyen Vi Anh Le Ngoc Khanh Nam Tran Hanh Vy Tran |
| author_sort | Van Thanh Le Thai |
| collection | DOAJ |
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Introduction: Infiltrative anesthesia with lidocaine plays a vital role in pain management during dermatologic procedures, ensuring patient comfort throughout the process.
Objective: We aimed to investigate the correlation between three different concentrations of lidocaine (2% lidocaine with 1:100,000 epinephrine diluted at ratios of 1:2, 1:4, and 1:6) used in infiltrative anesthesia and their analgesic efficacy and adverse effects in dermatologic procedures.
Methods: This study employed a randomized design, with 240 patients assigned to receive varying concentrations of lidocaine with epinephrine (2% lidocaine with 1:100,000 epinephrine diluted at ratios of 1:2, 1:4, or 1:6) during 7 common dermatologic procedures: punch biopsy, excisional biopsy, CO2 laser biopsy, surgical excision, CO2 laser excision, fractional CO2 laser treatment, and filler injection. Total lidocaine dosage and patient comfort assessments were recorded for each participant.
Results: All 3 lidocaine concentrations demonstrated comparable analgesic efficacy during the procedures, as measured by visual analog scale scores. The 1:6 dilution group required a significantly lower lidocaine dose, with a 69.3% reduction compared to the 1:4 dilution group and an 87.5% reduction compared to the 1:2 dilution group (p < 0.001). The 1:6 dilution group experienced significantly less pain during injection than that of the 1:4 dilution group and the 1:2 dilution group (p < 0.001).
Conclusion: Lidocaine 2% with 1:100,000 epinephrine at dilutions ranging from 1:2 to 1:6 for infiltrative anesthesia in dermatologic procedures provided similar analgesic efficacy. Importantly, the 1:6 dilution significantly reduced both injection pain and total lidocaine dosage. More studies are required to confirm our results.
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| format | Article |
| id | doaj-art-35958a3bbe4844dea9947b2fd020cc18 |
| institution | DOAJ |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Mattioli1885 |
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| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-35958a3bbe4844dea9947b2fd020cc182025-08-20T03:06:19ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-07-0115310.5826/dpc.1503a5382Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative AnesthesiaVan Thanh Le Thai0Tri Thong Nguyen1Quoc Hung Ta2Anh Tuan Ngo3Thanh Yen Thai Thanh Yen4Phuong Thao Nguyen5Vi Anh Le6Ngoc Khanh Nam Tran7Hanh Vy Tran8University Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamUniversity Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamUniversity Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamUniversity Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamUniversity Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamUniversity Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamUniversity Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamUniversity Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamUniversity Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam Introduction: Infiltrative anesthesia with lidocaine plays a vital role in pain management during dermatologic procedures, ensuring patient comfort throughout the process. Objective: We aimed to investigate the correlation between three different concentrations of lidocaine (2% lidocaine with 1:100,000 epinephrine diluted at ratios of 1:2, 1:4, and 1:6) used in infiltrative anesthesia and their analgesic efficacy and adverse effects in dermatologic procedures. Methods: This study employed a randomized design, with 240 patients assigned to receive varying concentrations of lidocaine with epinephrine (2% lidocaine with 1:100,000 epinephrine diluted at ratios of 1:2, 1:4, or 1:6) during 7 common dermatologic procedures: punch biopsy, excisional biopsy, CO2 laser biopsy, surgical excision, CO2 laser excision, fractional CO2 laser treatment, and filler injection. Total lidocaine dosage and patient comfort assessments were recorded for each participant. Results: All 3 lidocaine concentrations demonstrated comparable analgesic efficacy during the procedures, as measured by visual analog scale scores. The 1:6 dilution group required a significantly lower lidocaine dose, with a 69.3% reduction compared to the 1:4 dilution group and an 87.5% reduction compared to the 1:2 dilution group (p < 0.001). The 1:6 dilution group experienced significantly less pain during injection than that of the 1:4 dilution group and the 1:2 dilution group (p < 0.001). Conclusion: Lidocaine 2% with 1:100,000 epinephrine at dilutions ranging from 1:2 to 1:6 for infiltrative anesthesia in dermatologic procedures provided similar analgesic efficacy. Importantly, the 1:6 dilution significantly reduced both injection pain and total lidocaine dosage. More studies are required to confirm our results. https://dpcj.org/index.php/dpc/article/view/5382lidocaineinfiltrative anesthesiadermatologic proceduresVAS |
| spellingShingle | Van Thanh Le Thai Tri Thong Nguyen Quoc Hung Ta Anh Tuan Ngo Thanh Yen Thai Thanh Yen Phuong Thao Nguyen Vi Anh Le Ngoc Khanh Nam Tran Hanh Vy Tran Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia Dermatology Practical & Conceptual lidocaine infiltrative anesthesia dermatologic procedures VAS |
| title | Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia |
| title_full | Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia |
| title_fullStr | Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia |
| title_full_unstemmed | Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia |
| title_short | Impact of Lidocaine Concentration on Analgesic Efficacy and Adverse Events in Dermatologic Infiltrative Anesthesia |
| title_sort | impact of lidocaine concentration on analgesic efficacy and adverse events in dermatologic infiltrative anesthesia |
| topic | lidocaine infiltrative anesthesia dermatologic procedures VAS |
| url | https://dpcj.org/index.php/dpc/article/view/5382 |
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