Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis
Prostate cancer exhibits significant racial disparities, with African American (AA) individuals showing ∼64% higher incidence and 2.3 times greater mortality rates compared to their Caucasian (CA) counterparts. Understanding the complex interplay of genetic, environmental, lifestyle, socioeconomic,...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-04-01
|
| Series: | Cell Insight |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892725000124 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850187780189061120 |
|---|---|
| author | Abdalla Elbialy Akshay Sood Shang-Jui Wang Peng Wang Ahmed Fadiel Anil V. Parwani Steven Huang Gennady Shvets Nagireddy Putluri Jenny Li Xuefeng Liu |
| author_facet | Abdalla Elbialy Akshay Sood Shang-Jui Wang Peng Wang Ahmed Fadiel Anil V. Parwani Steven Huang Gennady Shvets Nagireddy Putluri Jenny Li Xuefeng Liu |
| author_sort | Abdalla Elbialy |
| collection | DOAJ |
| description | Prostate cancer exhibits significant racial disparities, with African American (AA) individuals showing ∼64% higher incidence and 2.3 times greater mortality rates compared to their Caucasian (CA) counterparts. Understanding the complex interplay of genetic, environmental, lifestyle, socioeconomic, and healthcare access factors is crucial for developing effective interventions to reduce this disproportionate burden.This study aims to uncover the genetic and transcriptomic differences driving these disparities through a comprehensive analysis using RNA sequencing (RNA-seq) and exome sequencing of prostate cancer tissues from both Black and White patients.Our transcriptomics analysis revealed enhanced activity in pathways linked to immune response and cellular interactions in AA prostate cancer samples, with notable regulation by histone-associated transcription factors (HIST1H1A, HIST1H1D, and HIST1H1B) suggests potential involvement of histone modification mechanisms. Additionally, pseudogenes and long non-coding RNAs (lncRNAs) among the regulated genes indicate non-coding elements' role in these disparities.Exome sequencing identified unique variants in AA patient samples within key genes, including TP73 (tumor suppression), XYLB (metabolism), ALDH4A1 (oxidative stress), PTPRB (cellular signaling), and HLA-DRB5 (immune response). These genetic variations likely contribute to disease progression and therapy response disparities.This study highlights the importance of considering genetic and epigenetic variations in developing tailored therapeutic approaches to improve treatment efficacy and reduce mortality rates across diverse populations. |
| format | Article |
| id | doaj-art-3594846d1d2840a8ba850dcf32fd28be |
| institution | OA Journals |
| issn | 2772-8927 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj-art-3594846d1d2840a8ba850dcf32fd28be2025-08-20T02:16:02ZengElsevierCell Insight2772-89272025-04-014210023810.1016/j.cellin.2025.100238Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysisAbdalla Elbialy0Akshay Sood1Shang-Jui Wang2Peng Wang3Ahmed Fadiel4Anil V. Parwani5Steven Huang6Gennady Shvets7Nagireddy Putluri8Jenny Li9Xuefeng Liu10OSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA; Computational Oncology Unit, The University of Chicago Comprehensive Cancer Center, 900 E 57th Street, KCBD Bldg., STE 4144, Chicago, IL, 60637, USAOSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA; Department of Urology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USAOSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA; Department of Radiation Oncology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USAOSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA; Department of Medicine, College of Medicine, The Ohio State University, Columbus, OH, 3210, USAComputational Oncology Unit, The University of Chicago Comprehensive Cancer Center, 900 E 57th Street, KCBD Bldg., STE 4144, Chicago, IL, 60637, USAOSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA; Departments of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USASchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, 14850, USASchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, 14850, USADepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USAOSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA; Departments of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USAOSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA; Departments of Pathology, Urology, and Radiation Oncology, College of Medicine, The Ohio StateUniversity, Columbus, OH, 43210, USA; Corresponding author. OSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.Prostate cancer exhibits significant racial disparities, with African American (AA) individuals showing ∼64% higher incidence and 2.3 times greater mortality rates compared to their Caucasian (CA) counterparts. Understanding the complex interplay of genetic, environmental, lifestyle, socioeconomic, and healthcare access factors is crucial for developing effective interventions to reduce this disproportionate burden.This study aims to uncover the genetic and transcriptomic differences driving these disparities through a comprehensive analysis using RNA sequencing (RNA-seq) and exome sequencing of prostate cancer tissues from both Black and White patients.Our transcriptomics analysis revealed enhanced activity in pathways linked to immune response and cellular interactions in AA prostate cancer samples, with notable regulation by histone-associated transcription factors (HIST1H1A, HIST1H1D, and HIST1H1B) suggests potential involvement of histone modification mechanisms. Additionally, pseudogenes and long non-coding RNAs (lncRNAs) among the regulated genes indicate non-coding elements' role in these disparities.Exome sequencing identified unique variants in AA patient samples within key genes, including TP73 (tumor suppression), XYLB (metabolism), ALDH4A1 (oxidative stress), PTPRB (cellular signaling), and HLA-DRB5 (immune response). These genetic variations likely contribute to disease progression and therapy response disparities.This study highlights the importance of considering genetic and epigenetic variations in developing tailored therapeutic approaches to improve treatment efficacy and reduce mortality rates across diverse populations.http://www.sciencedirect.com/science/article/pii/S2772892725000124Racial disparitiesProstate cancerGenomicsTranscriptomicsEtiologyDifferential analysis |
| spellingShingle | Abdalla Elbialy Akshay Sood Shang-Jui Wang Peng Wang Ahmed Fadiel Anil V. Parwani Steven Huang Gennady Shvets Nagireddy Putluri Jenny Li Xuefeng Liu Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis Cell Insight Racial disparities Prostate cancer Genomics Transcriptomics Etiology Differential analysis |
| title | Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis |
| title_full | Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis |
| title_fullStr | Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis |
| title_full_unstemmed | Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis |
| title_short | Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis |
| title_sort | unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis |
| topic | Racial disparities Prostate cancer Genomics Transcriptomics Etiology Differential analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2772892725000124 |
| work_keys_str_mv | AT abdallaelbialy unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT akshaysood unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT shangjuiwang unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT pengwang unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT ahmedfadiel unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT anilvparwani unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT stevenhuang unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT gennadyshvets unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT nagireddyputluri unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT jennyli unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis AT xuefengliu unveilingracialdisparitiesinprostatecancerusinganintegrativegenomicandtranscriptomicanalysis |