EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment.

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment.

Suppression of HIV replication by antiretroviral therapy (ART) or host immunity can prevent AIDS but not other HIV-associated conditions including neurocognitive impairment (HIV-NCI). Pathogenesis in HIV-suppressed individuals has been attributed to reservoirs of latent-inducible virus in resting CD...

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Bibliographic Details
Main Authors: Chao-Jiang Gu, Alejandra Borjabad, Eran Hadas, Jennifer Kelschenbach, Boe-Hyun Kim, Wei Chao, Ottavio Arancio, Jin Suh, Bruce Polsky, JoEllyn McMillan, Benson Edagwa, Howard E Gendelman, Mary Jane Potash, David J Volsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Pathogens
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.ppat.1007061/1/ppat.1007061.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T182946Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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