Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties

Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties

Nipocalimab is a human immunoglobulin G (IgG)1 monoclonal antibody that binds to the neonatal Fc receptor (FcRn) with high specificity and high affinity at both neutral (extracellular) and acidic (intracellular) pH, resulting in the reduction of circulating IgG levels, including those of pathogenic...

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Bibliographic Details
Main Authors: Nilufer P. Seth, Rui Xu, Matthew DuPrie, Amit Choudhury, Samuel Sihapong, Steven Tyler, James Meador, William Avery, Edward Cochran, Thomas Daly, Julia Brown, Laura Rutitzky, Lynn Markowitz, Sujatha Kumar, Traymon Beavers, Sayak Bhattacharya, Hsin Chen, Viraj Parge, Karen Price, Yang Wang, Siddharth Sukumaran, Yvonne Pao, Katie Abouzahr, Fiona Elwood, Jay Duffner, Sucharita Roy, Pushpa Narayanaswami, Jonathan J. Hubbard, Leona E. Ling
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Adaptive immune functions
FcRn blockers
in vivo models
innate immune functions
molecular properties
pharmacologic properties
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2461191
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