Application of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goats
Progesterone (P4)-impregnated controlled internal drug-releasing device for goats and sheep (CIDR-G) is used in the estrus synchronization protocol; however, it is not commercially available in Japan. In this study, we investigated whether a modification of CIDR-B, designed for cattle, could be used...
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| Language: | English |
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The Society for Reproduction and Development
2024-11-01
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| Series: | The Journal of Reproduction and Development |
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| Online Access: | https://www.jstage.jst.go.jp/article/jrd/70/6/70_2024-083/_pdf/-char/en |
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| _version_ | 1846126337880752128 |
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| author | Kotaro SAITO Tomomi TANAKA Natsumi ENDO |
| author_facet | Kotaro SAITO Tomomi TANAKA Natsumi ENDO |
| author_sort | Kotaro SAITO |
| collection | DOAJ |
| description | Progesterone (P4)-impregnated controlled internal drug-releasing device for goats and sheep (CIDR-G) is used in the estrus synchronization protocol; however, it is not commercially available in Japan. In this study, we investigated whether a modification of CIDR-B, designed for cattle, could be used as a P4 release device for synchronizing estrus in goats. An in vitro analysis showed that the dissolution rate was not significantly different between CIDR-G and modified CIDR-B (CIDR-M). The administration of CIDR-G or CIDR-M to dairy goats resulted in plasma P4 concentrations being maintained at the functional luteal phase levels (>2 ng/ml) in both groups for 12 days after administration. However, P4 concentrations at 2, 4, and 8 days after the administration of CIDR-G were significantly higher than those after the administration of CIDR-M. These results suggest that the CIDR-M examined in this study can maintain P4 levels for 12 days after its administration as a P4 release device. |
| format | Article |
| id | doaj-art-3590e14ae9704aad81e9e36d1ccc403b |
| institution | Kabale University |
| issn | 0916-8818 1348-4400 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | The Society for Reproduction and Development |
| record_format | Article |
| series | The Journal of Reproduction and Development |
| spelling | doaj-art-3590e14ae9704aad81e9e36d1ccc403b2024-12-12T23:49:43ZengThe Society for Reproduction and DevelopmentThe Journal of Reproduction and Development0916-88181348-44002024-11-0170642342610.1262/jrd.2024-083jrdApplication of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goatsKotaro SAITO0Tomomi TANAKA1Natsumi ENDO2Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, JapanLaboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, JapanLaboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, JapanProgesterone (P4)-impregnated controlled internal drug-releasing device for goats and sheep (CIDR-G) is used in the estrus synchronization protocol; however, it is not commercially available in Japan. In this study, we investigated whether a modification of CIDR-B, designed for cattle, could be used as a P4 release device for synchronizing estrus in goats. An in vitro analysis showed that the dissolution rate was not significantly different between CIDR-G and modified CIDR-B (CIDR-M). The administration of CIDR-G or CIDR-M to dairy goats resulted in plasma P4 concentrations being maintained at the functional luteal phase levels (>2 ng/ml) in both groups for 12 days after administration. However, P4 concentrations at 2, 4, and 8 days after the administration of CIDR-G were significantly higher than those after the administration of CIDR-M. These results suggest that the CIDR-M examined in this study can maintain P4 levels for 12 days after its administration as a P4 release device.https://www.jstage.jst.go.jp/article/jrd/70/6/70_2024-083/_pdf/-char/enbreeding seasondissolution testestrus synchronizationgoatsintravaginal progesterone device |
| spellingShingle | Kotaro SAITO Tomomi TANAKA Natsumi ENDO Application of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goats The Journal of Reproduction and Development breeding season dissolution test estrus synchronization goats intravaginal progesterone device |
| title | Application of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goats |
| title_full | Application of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goats |
| title_fullStr | Application of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goats |
| title_full_unstemmed | Application of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goats |
| title_short | Application of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goats |
| title_sort | application of bovine progesterone intravaginal controlled release formulation for estrus synchronization treatment in goats |
| topic | breeding season dissolution test estrus synchronization goats intravaginal progesterone device |
| url | https://www.jstage.jst.go.jp/article/jrd/70/6/70_2024-083/_pdf/-char/en |
| work_keys_str_mv | AT kotarosaito applicationofbovineprogesteroneintravaginalcontrolledreleaseformulationforestrussynchronizationtreatmentingoats AT tomomitanaka applicationofbovineprogesteroneintravaginalcontrolledreleaseformulationforestrussynchronizationtreatmentingoats AT natsumiendo applicationofbovineprogesteroneintravaginalcontrolledreleaseformulationforestrussynchronizationtreatmentingoats |