The Role of MicroRNAs in Diabetic Nephropathy
Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulat...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/920134 |
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| author | Hao Wu Lili Kong Shanshan Zhou Wenpeng Cui Feng Xu Manyu Luo Xiangqi Li Yi Tan Lining Miao |
| author_facet | Hao Wu Lili Kong Shanshan Zhou Wenpeng Cui Feng Xu Manyu Luo Xiangqi Li Yi Tan Lining Miao |
| author_sort | Hao Wu |
| collection | DOAJ |
| description | Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention. |
| format | Article |
| id | doaj-art-358b79aa990844b5bc4b88513af3200c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-358b79aa990844b5bc4b88513af3200c2025-02-03T01:31:58ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/920134920134The Role of MicroRNAs in Diabetic NephropathyHao Wu0Lili Kong1Shanshan Zhou2Wenpeng Cui3Feng Xu4Manyu Luo5Xiangqi Li6Yi Tan7Lining Miao8Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaKosair Children’s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USADepartment of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, ChinaChinese-American Research Institute for Diabetic Complications at Wenzhou Medical University, Wenzhou 325035, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, ChinaDiabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.http://dx.doi.org/10.1155/2014/920134 |
| spellingShingle | Hao Wu Lili Kong Shanshan Zhou Wenpeng Cui Feng Xu Manyu Luo Xiangqi Li Yi Tan Lining Miao The Role of MicroRNAs in Diabetic Nephropathy Journal of Diabetes Research |
| title | The Role of MicroRNAs in Diabetic Nephropathy |
| title_full | The Role of MicroRNAs in Diabetic Nephropathy |
| title_fullStr | The Role of MicroRNAs in Diabetic Nephropathy |
| title_full_unstemmed | The Role of MicroRNAs in Diabetic Nephropathy |
| title_short | The Role of MicroRNAs in Diabetic Nephropathy |
| title_sort | role of micrornas in diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2014/920134 |
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