Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot Study
<b>Background/Objectives:</b> Juvenile idiopathic arthritis (JIA) is a chronic childhood disease that often persists into the reproductive years. JIA may impact long-term fertility due to the prolonged exposure to immunosuppressive therapies. <b>Methods:</b> A total of 35 adu...
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2024-10-01
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| author | Clara Di Mario Maria Rita Gigante Angelina Barini Luca Petricca Antonella Barini Antonio Bianchi Stefano Alivernini Barbara Tolusso Elisa Gremese |
| author_facet | Clara Di Mario Maria Rita Gigante Angelina Barini Luca Petricca Antonella Barini Antonio Bianchi Stefano Alivernini Barbara Tolusso Elisa Gremese |
| author_sort | Clara Di Mario |
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| description | <b>Background/Objectives:</b> Juvenile idiopathic arthritis (JIA) is a chronic childhood disease that often persists into the reproductive years. JIA may impact long-term fertility due to the prolonged exposure to immunosuppressive therapies. <b>Methods:</b> A total of 35 adult JIA female patients of childbearing age and 20 age-matched healthy controls were studied to test their anti-Müllerian hormone (AMH) serum levels as a biomarker of ovarian reserve. Demographic characteristics, disease duration, previous and current treatments, disease activity (DAS44), and a health assessment questionnaire (HAQ) were recorded. <b>Results:</b> JIA patients had a mean age of 22.3 ± 2.9 years, a disease duration of 12.3 ± 6.1 years, and a DAS44 of 1.24 ± 0.61. No differences were found in AMH serum levels between JIA and controls (5.78 ± 2.37 ng/mL vs. 6.60 ± 2.68 ng/mL, respectively; <i>p</i> = 0.17). Among the patients, 22 (62.9%) were receiving a stable dose of methotrexate (MTX) and 19 (54.3%) a dose of TNFα inhibitors. No difference in AMH serum levels was observed between JIA patients who were or were not exposed to MTX (<i>p</i> = 0.29) or to TNFα inhibitors (<i>p</i> = 0.50). <b>Conclusions:</b> Ovarian reserve as assessed by AMH serum levels appears to be comparable between those with JIA and age-matched controls and does not appear to be influenced by disease characteristics or prior/concomitant exposure to immunosuppressive drugs. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2024-10-01 |
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| spelling | doaj-art-3588fb5c519b4ce7b9dfecab8c56b2a42024-12-27T14:11:22ZengMDPI AGBioChem2673-64112024-10-014431332210.3390/biochem4040016Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot StudyClara Di Mario0Maria Rita Gigante1Angelina Barini2Luca Petricca3Antonella Barini4Antonio Bianchi5Stefano Alivernini6Barbara Tolusso7Elisa Gremese8Immunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDivision of Rheumathology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyChemistry, Biochemistry and Molecular Biology Clinic, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDivision of Rheumathology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyChemistry, Biochemistry and Molecular Biology Clinic, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyEndocrinology and Diabetes Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyImmunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyImmunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyImmunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy<b>Background/Objectives:</b> Juvenile idiopathic arthritis (JIA) is a chronic childhood disease that often persists into the reproductive years. JIA may impact long-term fertility due to the prolonged exposure to immunosuppressive therapies. <b>Methods:</b> A total of 35 adult JIA female patients of childbearing age and 20 age-matched healthy controls were studied to test their anti-Müllerian hormone (AMH) serum levels as a biomarker of ovarian reserve. Demographic characteristics, disease duration, previous and current treatments, disease activity (DAS44), and a health assessment questionnaire (HAQ) were recorded. <b>Results:</b> JIA patients had a mean age of 22.3 ± 2.9 years, a disease duration of 12.3 ± 6.1 years, and a DAS44 of 1.24 ± 0.61. No differences were found in AMH serum levels between JIA and controls (5.78 ± 2.37 ng/mL vs. 6.60 ± 2.68 ng/mL, respectively; <i>p</i> = 0.17). Among the patients, 22 (62.9%) were receiving a stable dose of methotrexate (MTX) and 19 (54.3%) a dose of TNFα inhibitors. No difference in AMH serum levels was observed between JIA patients who were or were not exposed to MTX (<i>p</i> = 0.29) or to TNFα inhibitors (<i>p</i> = 0.50). <b>Conclusions:</b> Ovarian reserve as assessed by AMH serum levels appears to be comparable between those with JIA and age-matched controls and does not appear to be influenced by disease characteristics or prior/concomitant exposure to immunosuppressive drugs.https://www.mdpi.com/2673-6411/4/4/16juvenile idiopathic arthritisanti-Müllerian hormoneimmunosuppressive drugs |
| spellingShingle | Clara Di Mario Maria Rita Gigante Angelina Barini Luca Petricca Antonella Barini Antonio Bianchi Stefano Alivernini Barbara Tolusso Elisa Gremese Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot Study BioChem juvenile idiopathic arthritis anti-Müllerian hormone immunosuppressive drugs |
| title | Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot Study |
| title_full | Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot Study |
| title_fullStr | Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot Study |
| title_full_unstemmed | Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot Study |
| title_short | Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot Study |
| title_sort | anti mullerian hormone serum levels as biomarker of ovarian reserve in adult women with juvenile idiopathic arthritis treated with csdmards and or bdmards a pilot study |
| topic | juvenile idiopathic arthritis anti-Müllerian hormone immunosuppressive drugs |
| url | https://www.mdpi.com/2673-6411/4/4/16 |
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