ESM1 suppresses LncRNA GAS5/miR-23a-3p/PTEN axis to promote the cisplatin-chemotherapy resistance of ovarian cancer cells via activating the PI3K/AKT pathway

ESM1 suppresses LncRNA GAS5/miR-23a-3p/PTEN axis to promote the cisplatin-chemotherapy resistance of ovarian cancer cells via activating the PI3K/AKT pathway

Abstract Background Cisplatin chemotherapy is an important treatment for advanced ovarian cancer (OC). However, the development of cisplatin resistance greatly limits the survival time of OC patients. Endothelial cell-specific molecule 1 (ESM1) has been found to be an important proto-oncogene promot...

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Main Authors: Hui Li, Tingyu Fan, Mei Qin, Shuanghua Chen, Wenchao Zhou, Peiting Wu, Yuwei Yuan, Xing Tang, Tian Zeng, Jiawen Fang, Ting Yi, Juan Zhang, Juan Zou, Yukun Li
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Discover Oncology
Subjects:
Ovarian cancer
ESM1
GAS5
PTEN/PI3K/AKT pathway
Cisplatin resistance
Online Access:https://doi.org/10.1007/s12672-025-02113-1
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