Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study
Aim of investigation. To estimate diagnostic value of liver and spleen elastography in patients with extrahepatic portal vein obstruction - non-cirrhotic portal vein thrombosis (PVT). Material and methods. The study group: 19 patients (Age 21-76 years) with PVT diagnosed by multispiral computed angi...
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/72 |
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| author | M. Yu. Nadinskaya Ye. O. Liusina Ch. S. Pavlov |
| author_facet | M. Yu. Nadinskaya Ye. O. Liusina Ch. S. Pavlov |
| author_sort | M. Yu. Nadinskaya |
| collection | DOAJ |
| description | Aim of investigation. To estimate diagnostic value of liver and spleen elastography in patients with extrahepatic portal vein obstruction - non-cirrhotic portal vein thrombosis (PVT). Material and methods. The study group: 19 patients (Age 21-76 years) with PVT diagnosed by multispiral computed angiography without liver/pancreatobiliary tumors and/or liver cirrhosis (LC). The comparison group included 23 patients with LC Child-Pugh class A. Past history of portal hypertension, platelet count, serum albumin level, alanine and aspartate aminotransferase level; prothrombin according to international normalization ratio; grade of esophageal varices (EV); spleen longitudinal size according to abdominal ultrasound, liver and spleen stiffness were evaluated in both groups. Results. The group of patients with non-cirrhotic PVT was characterized by presence of clinically significant portal hypertension (EV, splenomegaly and hypersplenism). Following causes for PVT were established: systemic factors - myeloproliferative diseases, G20210A prothrombin gene mutation, and local factors: complications after pancreatobiliary surgery, omphalitis and neonatal umbilical sepsis. Nine patients, 1 to 2 years prior to hospitalization, were previously misclassified as «cryptogenic liver cirrhosis» in various medical institutions. Liver stiffness in PVT group was 2,8-11,5 kPa. The grade of EV tended to increase along with progression of the spleen stiffness. Statistically significant difference in serum aminotransferases levels in non-cirrhotic PVT vs Child-Pugh class A HCV-LC was observed: enzyme levels were 1,5-2 fold higher in LC (р |
| format | Article |
| id | doaj-art-3585527c2623491e8aca5931b34e043c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-3585527c2623491e8aca5931b34e043c2025-02-10T16:14:28ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01264627010.22416/1382-4376-2016-4-62-7072Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot studyM. Yu. Nadinskaya0Ye. O. Liusina1Ch. S. Pavlov2State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»Aim of investigation. To estimate diagnostic value of liver and spleen elastography in patients with extrahepatic portal vein obstruction - non-cirrhotic portal vein thrombosis (PVT). Material and methods. The study group: 19 patients (Age 21-76 years) with PVT diagnosed by multispiral computed angiography without liver/pancreatobiliary tumors and/or liver cirrhosis (LC). The comparison group included 23 patients with LC Child-Pugh class A. Past history of portal hypertension, platelet count, serum albumin level, alanine and aspartate aminotransferase level; prothrombin according to international normalization ratio; grade of esophageal varices (EV); spleen longitudinal size according to abdominal ultrasound, liver and spleen stiffness were evaluated in both groups. Results. The group of patients with non-cirrhotic PVT was characterized by presence of clinically significant portal hypertension (EV, splenomegaly and hypersplenism). Following causes for PVT were established: systemic factors - myeloproliferative diseases, G20210A prothrombin gene mutation, and local factors: complications after pancreatobiliary surgery, omphalitis and neonatal umbilical sepsis. Nine patients, 1 to 2 years prior to hospitalization, were previously misclassified as «cryptogenic liver cirrhosis» in various medical institutions. Liver stiffness in PVT group was 2,8-11,5 kPa. The grade of EV tended to increase along with progression of the spleen stiffness. Statistically significant difference in serum aminotransferases levels in non-cirrhotic PVT vs Child-Pugh class A HCV-LC was observed: enzyme levels were 1,5-2 fold higher in LC (рhttps://www.gastro-j.ru/jour/article/view/72эластографияпеченьселезенкадиагностикавнепеченочная обструкция воротной вены |
| spellingShingle | M. Yu. Nadinskaya Ye. O. Liusina Ch. S. Pavlov Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study Российский журнал гастроэнтерологии, гепатологии, колопроктологии эластография печень селезенка диагностика внепеченочная обструкция воротной вены |
| title | Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study |
| title_full | Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study |
| title_fullStr | Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study |
| title_full_unstemmed | Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study |
| title_short | Liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction: pilot study |
| title_sort | liver and spleen elastography in diagnosis of extrahepatic portal vein obstruction pilot study |
| topic | эластография печень селезенка диагностика внепеченочная обструкция воротной вены |
| url | https://www.gastro-j.ru/jour/article/view/72 |
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