Dissolution Enhancement of Meloxicam Tablets from the Synergistic Effect of Hydrotropic and Sublimating Agent
Drugs which fall into Class II of Biopharmaceutical Classification System suffer from poor aqueous solubility that limits the dissolution and oral bioavailability. The improvement of the dissolution rate of this class of drug is an important issue for enhancing their bioavailability and therapeutic...
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| Format: | Article |
| Language: | English |
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Erbil Polytechnic University
2021-12-01
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| Series: | Polytechnic Journal |
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| Online Access: | https://polytechnic-journal.epu.edu.iq/home/vol11/iss2/16 |
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| author | Hemn L. Qader Tara A. Abdula Huner K. Omer |
| author_facet | Hemn L. Qader Tara A. Abdula Huner K. Omer |
| author_sort | Hemn L. Qader |
| collection | DOAJ |
| description | Drugs which fall into Class II of Biopharmaceutical Classification System
suffer from poor aqueous solubility that limits the dissolution and oral bioavailability. The improvement
of the dissolution rate of this class of drug is an important issue for enhancing their bioavailability and
therapeutic efficacy. The objective of this study is to investigate the magnitude of enhancement of the
dissolution rate of Class II drug “Meloxicam (MLX)” by using more than one solubility enhancement
technique. |
| format | Article |
| id | doaj-art-35847ec6d1604274abe32632ef5cb025 |
| institution | OA Journals |
| issn | 2707-7799 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Erbil Polytechnic University |
| record_format | Article |
| series | Polytechnic Journal |
| spelling | doaj-art-35847ec6d1604274abe32632ef5cb0252025-08-20T02:01:35ZengErbil Polytechnic UniversityPolytechnic Journal2707-77992021-12-01112100108https://doi.org/10.25156/ptj.v11n2y2021.pp100-108Dissolution Enhancement of Meloxicam Tablets from the Synergistic Effect of Hydrotropic and Sublimating AgentHemn L. Qader0Tara A. Abdula1Huner K. Omer2Department of Pharmaceutics, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan region, IraqDepartment of Pharmaceutics, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan region, IraqDepartment of Pharmaceutics, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan region, IraqDrugs which fall into Class II of Biopharmaceutical Classification System suffer from poor aqueous solubility that limits the dissolution and oral bioavailability. The improvement of the dissolution rate of this class of drug is an important issue for enhancing their bioavailability and therapeutic efficacy. The objective of this study is to investigate the magnitude of enhancement of the dissolution rate of Class II drug “Meloxicam (MLX)” by using more than one solubility enhancement technique.https://polytechnic-journal.epu.edu.iq/home/vol11/iss2/16meloxicam,solubility,solid dispersion,sublimationcamphor |
| spellingShingle | Hemn L. Qader Tara A. Abdula Huner K. Omer Dissolution Enhancement of Meloxicam Tablets from the Synergistic Effect of Hydrotropic and Sublimating Agent Polytechnic Journal meloxicam, solubility, solid dispersion, sublimation camphor |
| title | Dissolution Enhancement of Meloxicam Tablets from the Synergistic Effect of Hydrotropic and Sublimating Agent |
| title_full | Dissolution Enhancement of Meloxicam Tablets from the Synergistic Effect of Hydrotropic and Sublimating Agent |
| title_fullStr | Dissolution Enhancement of Meloxicam Tablets from the Synergistic Effect of Hydrotropic and Sublimating Agent |
| title_full_unstemmed | Dissolution Enhancement of Meloxicam Tablets from the Synergistic Effect of Hydrotropic and Sublimating Agent |
| title_short | Dissolution Enhancement of Meloxicam Tablets from the Synergistic Effect of Hydrotropic and Sublimating Agent |
| title_sort | dissolution enhancement of meloxicam tablets from the synergistic effect of hydrotropic and sublimating agent |
| topic | meloxicam, solubility, solid dispersion, sublimation camphor |
| url | https://polytechnic-journal.epu.edu.iq/home/vol11/iss2/16 |
| work_keys_str_mv | AT hemnlqader dissolutionenhancementofmeloxicamtabletsfromthesynergisticeffectofhydrotropicandsublimatingagent AT taraaabdula dissolutionenhancementofmeloxicamtabletsfromthesynergisticeffectofhydrotropicandsublimatingagent AT hunerkomer dissolutionenhancementofmeloxicamtabletsfromthesynergisticeffectofhydrotropicandsublimatingagent |