Heart failure in diabetes: From an increased risk to a treatment target
Heart failure (HF) is one of the most common comorbidities of type 2 diabetes mellitus (T2DM) and poor glycaemic control can worsen the HF outcomes and increase the risk of hospitalisations. With the entry of several antihyperglycaemic agents for the management of T2DM over the last decade, there ha...
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Endocrinology Research Centre
2018-11-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/9846 |
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| author | Eberhard Standl |
| author_facet | Eberhard Standl |
| author_sort | Eberhard Standl |
| collection | DOAJ |
| description | Heart failure (HF) is one of the most common comorbidities of type 2 diabetes mellitus (T2DM) and poor glycaemic control can worsen the HF outcomes and increase the risk of hospitalisations. With the entry of several antihyperglycaemic agents for the management of T2DM over the last decade, there has been an increasing concern regarding the cardiovascular (CV) safety profile of these agents. In view of this, FDA mandated the demonstration of cardiovascular risk-benefit profile of these agents through specifically designed CV outcome trials. Although we have several findings from these trials, none of them included HF as a primary endpoint indicating the need of trials focusing on HF. Here, we briefly discuss the results of the CV outcome trials in the context of HF. |
| format | Article |
| id | doaj-art-357945c2fd334a2ab4f8e387448d76be |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2018-11-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-357945c2fd334a2ab4f8e387448d76be2025-08-20T03:09:05ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782018-11-0121539940310.14341/DM98468583Heart failure in diabetes: From an increased risk to a treatment targetEberhard Standl0<p>Munich Diabetes Research Group e.V. at Helmholtz Center</p>Heart failure (HF) is one of the most common comorbidities of type 2 diabetes mellitus (T2DM) and poor glycaemic control can worsen the HF outcomes and increase the risk of hospitalisations. With the entry of several antihyperglycaemic agents for the management of T2DM over the last decade, there has been an increasing concern regarding the cardiovascular (CV) safety profile of these agents. In view of this, FDA mandated the demonstration of cardiovascular risk-benefit profile of these agents through specifically designed CV outcome trials. Although we have several findings from these trials, none of them included HF as a primary endpoint indicating the need of trials focusing on HF. Here, we briefly discuss the results of the CV outcome trials in the context of HF.https://www.dia-endojournals.ru/jour/article/view/9846type 2 diabetes mellitusheart failurecardiovascular outcome trialsdpp-4 inhibitorssglt-2 inhibitorsglp-1 receptor agonists |
| spellingShingle | Eberhard Standl Heart failure in diabetes: From an increased risk to a treatment target Сахарный диабет type 2 diabetes mellitus heart failure cardiovascular outcome trials dpp-4 inhibitors sglt-2 inhibitors glp-1 receptor agonists |
| title | Heart failure in diabetes: From an increased risk to a treatment target |
| title_full | Heart failure in diabetes: From an increased risk to a treatment target |
| title_fullStr | Heart failure in diabetes: From an increased risk to a treatment target |
| title_full_unstemmed | Heart failure in diabetes: From an increased risk to a treatment target |
| title_short | Heart failure in diabetes: From an increased risk to a treatment target |
| title_sort | heart failure in diabetes from an increased risk to a treatment target |
| topic | type 2 diabetes mellitus heart failure cardiovascular outcome trials dpp-4 inhibitors sglt-2 inhibitors glp-1 receptor agonists |
| url | https://www.dia-endojournals.ru/jour/article/view/9846 |
| work_keys_str_mv | AT eberhardstandl heartfailureindiabetesfromanincreasedrisktoatreatmenttarget |