Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients
The adipocyte-derived cytokine leptin was implicated to link inflammation and metabolic alterations. We investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia are common features of critical illness. Upon...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/473540 |
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| author | Alexander Koch Ralf Weiskirchen Henning W. Zimmermann Edouard Sanson Christian Trautwein Frank Tacke |
| author_facet | Alexander Koch Ralf Weiskirchen Henning W. Zimmermann Edouard Sanson Christian Trautwein Frank Tacke |
| author_sort | Alexander Koch |
| collection | DOAJ |
| description | The adipocyte-derived cytokine leptin was implicated to link inflammation and metabolic alterations. We investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia are common features of critical illness. Upon admission to Medical Intensive Care Unit (ICU), free leptin and soluble leptin-receptor serum concentrations were determined in 137 critically ill patients (95 with sepsis, 42 without sepsis) and 26 healthy controls. Serum leptin or leptin-receptor did not differ between patients or controls and were independent of sepsis. However, serum leptin was closely associated with obesity and diabetes and clearly correlated with markers of metabolism and liver function. Leptin-receptor was an unfavourable prognostic indicator, associated with mortality during three years follow-up. Our study indicates a functional role of leptin in the pathogenesis of severe illness and emphasizes the impact of complex metabolic alterations on the clinical outcome of critically ill patients. |
| format | Article |
| id | doaj-art-3571d678f6514feea6b70bb8d89f1940 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3571d678f6514feea6b70bb8d89f19402025-08-20T03:55:16ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/473540473540Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill PatientsAlexander Koch0Ralf Weiskirchen1Henning W. Zimmermann2Edouard Sanson3Christian Trautwein4Frank Tacke5Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyInstitute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, GermanyThe adipocyte-derived cytokine leptin was implicated to link inflammation and metabolic alterations. We investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia are common features of critical illness. Upon admission to Medical Intensive Care Unit (ICU), free leptin and soluble leptin-receptor serum concentrations were determined in 137 critically ill patients (95 with sepsis, 42 without sepsis) and 26 healthy controls. Serum leptin or leptin-receptor did not differ between patients or controls and were independent of sepsis. However, serum leptin was closely associated with obesity and diabetes and clearly correlated with markers of metabolism and liver function. Leptin-receptor was an unfavourable prognostic indicator, associated with mortality during three years follow-up. Our study indicates a functional role of leptin in the pathogenesis of severe illness and emphasizes the impact of complex metabolic alterations on the clinical outcome of critically ill patients.http://dx.doi.org/10.1155/2010/473540 |
| spellingShingle | Alexander Koch Ralf Weiskirchen Henning W. Zimmermann Edouard Sanson Christian Trautwein Frank Tacke Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients Mediators of Inflammation |
| title | Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients |
| title_full | Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients |
| title_fullStr | Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients |
| title_full_unstemmed | Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients |
| title_short | Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients |
| title_sort | relevance of serum leptin and leptin receptor concentrations in critically ill patients |
| url | http://dx.doi.org/10.1155/2010/473540 |
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