Investigating the effect of a herbal cream containing rose essence in an animal model of eczema
Objective: Eczema, a common inflammatory skin condition characterized by itching and dermatitis, can significantly impact the quality of life. While conventional treatments exist, there is interest in exploring natural alternatives. This study investigates the efficacy of a rosehip extract-based cre...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2025-03-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_25132_42de0b77713041826e8b8fb6d7db956c.pdf |
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| author | Ali Reza Malayeri Anayatollah Salimi Fariba Iraji Susan Sabbagh Neda Shakerian Mobin Khaledi |
| author_facet | Ali Reza Malayeri Anayatollah Salimi Fariba Iraji Susan Sabbagh Neda Shakerian Mobin Khaledi |
| author_sort | Ali Reza Malayeri |
| collection | DOAJ |
| description | Objective: Eczema, a common inflammatory skin condition characterized by itching and dermatitis, can significantly impact the quality of life. While conventional treatments exist, there is interest in exploring natural alternatives. This study investigates the efficacy of a rosehip extract-based cream in mitigating eczema symptoms in a mouse model.Materials and Methods: Thirty-five mice were divided into five groups: control, dinitrochlorobenzene (DNCB)-induced eczema (model group), and treatment groups receiving placebo, betamethasone cream (positive control), or rosehip extract cream. Following topical treatment for four weeks, the animals were euthanized, and their skin was evaluated for inflammation, moisture, and thickness. Histopathological analysis was performed using hematoxylin and eosin (H&E) staining.Results: Compared to the control group, DNCB treatment significantly increased inflammation, erythema (redness), dryness, and epidermal thickness. Notably, topical application of the rosehip extract cream significantly reduced these eczema-associated parameters, demonstrating efficacy comparable to the positive control (betamethasone cream).Conclusion: This study suggests that a topical cream formulated with rosehip extract may be a promising therapeutic strategy for alleviating eczema symptoms. The anti-inflammatory and potentially regenerative properties of rose extract warrant further investigation for the development of natural eczema treatments. |
| format | Article |
| id | doaj-art-3566dee6f0784dd3a36256fee1d161b5 |
| institution | OA Journals |
| issn | 2228-7930 2228-7949 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj-art-3566dee6f0784dd3a36256fee1d161b52025-08-20T01:51:24ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492025-03-011521070108110.22038/ajp.2024.2513225132Investigating the effect of a herbal cream containing rose essence in an animal model of eczemaAli Reza Malayeri0Anayatollah Salimi1Fariba Iraji2Susan Sabbagh3Neda Shakerian4Mobin Khaledi5Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranNanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Anatomical Sciences, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, IranDepartment of Clinical Biochemistry, Faculty of Medical Sciences, Dezful University of Medical Sciences, Dezful, IranMedicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranObjective: Eczema, a common inflammatory skin condition characterized by itching and dermatitis, can significantly impact the quality of life. While conventional treatments exist, there is interest in exploring natural alternatives. This study investigates the efficacy of a rosehip extract-based cream in mitigating eczema symptoms in a mouse model.Materials and Methods: Thirty-five mice were divided into five groups: control, dinitrochlorobenzene (DNCB)-induced eczema (model group), and treatment groups receiving placebo, betamethasone cream (positive control), or rosehip extract cream. Following topical treatment for four weeks, the animals were euthanized, and their skin was evaluated for inflammation, moisture, and thickness. Histopathological analysis was performed using hematoxylin and eosin (H&E) staining.Results: Compared to the control group, DNCB treatment significantly increased inflammation, erythema (redness), dryness, and epidermal thickness. Notably, topical application of the rosehip extract cream significantly reduced these eczema-associated parameters, demonstrating efficacy comparable to the positive control (betamethasone cream).Conclusion: This study suggests that a topical cream formulated with rosehip extract may be a promising therapeutic strategy for alleviating eczema symptoms. The anti-inflammatory and potentially regenerative properties of rose extract warrant further investigation for the development of natural eczema treatments.https://ajp.mums.ac.ir/article_25132_42de0b77713041826e8b8fb6d7db956c.pdfeczemarose extractdinitrochlorobenzenesmall laboratory mouserosa spp |
| spellingShingle | Ali Reza Malayeri Anayatollah Salimi Fariba Iraji Susan Sabbagh Neda Shakerian Mobin Khaledi Investigating the effect of a herbal cream containing rose essence in an animal model of eczema Avicenna Journal of Phytomedicine eczema rose extract dinitrochlorobenzene small laboratory mouse rosa spp |
| title | Investigating the effect of a herbal cream containing rose essence in an animal model of eczema |
| title_full | Investigating the effect of a herbal cream containing rose essence in an animal model of eczema |
| title_fullStr | Investigating the effect of a herbal cream containing rose essence in an animal model of eczema |
| title_full_unstemmed | Investigating the effect of a herbal cream containing rose essence in an animal model of eczema |
| title_short | Investigating the effect of a herbal cream containing rose essence in an animal model of eczema |
| title_sort | investigating the effect of a herbal cream containing rose essence in an animal model of eczema |
| topic | eczema rose extract dinitrochlorobenzene small laboratory mouse rosa spp |
| url | https://ajp.mums.ac.ir/article_25132_42de0b77713041826e8b8fb6d7db956c.pdf |
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