Risk factors of dialysis-related amyloidosis in maintenance hemodialysis patients
Objective To analyze the correlation between advanced glycosylation end products(AGE),free radical metabolism and dialysis-related amyloidosis(DRA) in the maintenance hemodialysis patients.Methods Serum AGE and Nercarboxymethyllysine(CML) in 46 cases of DRA diagnosed by shoulder R-ultrasound were te...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57920908&Fpath=home&index=0 |
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| Summary: | Objective To analyze the correlation between advanced glycosylation end products(AGE),free radical metabolism and dialysis-related amyloidosis(DRA) in the maintenance hemodialysis patients.Methods Serum AGE and Nercarboxymethyllysine(CML) in 46 cases of DRA diagnosed by shoulder R-ultrasound were tested.Superoxide dismutase(SOD),lipid peroxide(LPO),β2-microglobulin(β2-MG) and C-reactive protein(CRP) were detected.Results In DRA patients,AGE,CML,LPO,β2-MG and CRP levels were significantly increased,and SOD levels were significantly reduced as compared with control group(P<0.05 or P<0.01).With the prolonged duration of dialysis,EP-positive rate was significantly increased,and DRA aggravated.The AGE,CML,LPO,(32-MG and CRP levels were increased,and SOD levels reduced more significantly in the longterm dialysis group than the short-term dialysis group(P<0.05).Dialysis age was positively correlated with shoulder amyloidosis degree and levels of AGE,CML,LPO,β2-MG and CRP,but negatively with SOD levels(P<0.05 for all).The increases of AGE,(32-MG and CRP in maintenance hemodialysis may be the material basis of DRA early lesions.The enhanced oxidative stress and chronic inflammation may be involved in the formation process of the early DRA.Conclusions Preventing or delaying the development of DRA should reduce the circulating β2-MG levels and inhibit the joint inflammatioa Inhibiting the AGE decoration of β2-MC,clearing AGE decorative protein or blocking the interaction between AGE-β2-MG and cell surface receptor may be the way to prevent DRA or delay the development of DRA. |
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| ISSN: | 1671-2390 |