Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy
There is an increasing prevalence of non-communicable chronic diseases (NCCDs) like obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM), hypertension, allergic asthma, and neuro-developmental/psychiatric problems in many parts of the world. A suboptimal lifestyle as an adult is often blamed...
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MDPI AG
2024-11-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/11/11/1387 |
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| author | Manju Chandra |
| author_facet | Manju Chandra |
| author_sort | Manju Chandra |
| collection | DOAJ |
| description | There is an increasing prevalence of non-communicable chronic diseases (NCCDs) like obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM), hypertension, allergic asthma, and neuro-developmental/psychiatric problems in many parts of the world. A suboptimal lifestyle as an adult is often blamed for the occurrence of NCCDs. This review discusses the developmental origin of health and disease theory and how suboptimal nutrition in intrauterine life and the establishment of a suboptimal gut microbiome during infancy can influence the predisposition to NCCDs. |
| format | Article |
| id | doaj-art-355d764e28974a8a9e4533def4789a68 |
| institution | OA Journals |
| issn | 2227-9067 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-355d764e28974a8a9e4533def4789a682025-08-20T02:08:09ZengMDPI AGChildren2227-90672024-11-011111138710.3390/children11111387Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in InfancyManju Chandra0Division of Pediatric Nephrology, Department of Pediatrics, New York University Grossman Long Island School of Medicine, Mineola, NY 11501, USAThere is an increasing prevalence of non-communicable chronic diseases (NCCDs) like obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM), hypertension, allergic asthma, and neuro-developmental/psychiatric problems in many parts of the world. A suboptimal lifestyle as an adult is often blamed for the occurrence of NCCDs. This review discusses the developmental origin of health and disease theory and how suboptimal nutrition in intrauterine life and the establishment of a suboptimal gut microbiome during infancy can influence the predisposition to NCCDs.https://www.mdpi.com/2227-9067/11/11/1387DOHaDNCCDIUGRgut microbiome |
| spellingShingle | Manju Chandra Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy Children DOHaD NCCD IUGR gut microbiome |
| title | Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy |
| title_full | Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy |
| title_fullStr | Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy |
| title_full_unstemmed | Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy |
| title_short | Developmental Origins of Non-Communicable Chronic Diseases: Role of Fetal Undernutrition and Gut Dysbiosis in Infancy |
| title_sort | developmental origins of non communicable chronic diseases role of fetal undernutrition and gut dysbiosis in infancy |
| topic | DOHaD NCCD IUGR gut microbiome |
| url | https://www.mdpi.com/2227-9067/11/11/1387 |
| work_keys_str_mv | AT manjuchandra developmentaloriginsofnoncommunicablechronicdiseasesroleoffetalundernutritionandgutdysbiosisininfancy |