Single-cell transcriptome of mouse hippocampus identifies neural precursor-like cells, and reveals IL15Rα knock out-mediated neuron remodeling

Single-cell transcriptome of mouse hippocampus identifies neural precursor-like cells, and reveals IL15Rα knock out-mediated neuron remodeling

Abstract Background IL15Rα is highly expressed in brain tissues, especially in hippocampus. IL15Rα knock-out induces the behavior, physiological and molecular changes in mice similar to the phenotype of psychiatric disorders. Results To study how IL15Rα knock-out affects cellular function of the hip...

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Bibliographic Details
Main Authors: Yanting Luo, Yadan Nie, Xuemei Huang, Haixia Wang, Zuoli Sun, Jian Yang, Yi He
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Genomics
Subjects:
IL15Rα
Hippocampus
Single cell transcriptome
Precursor-like neural cell
Online Access:https://doi.org/10.1186/s12864-025-11785-6
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