MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity

MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity

Abstract Neuronal mitochondria are diverse across cell types and subcellular compartments in order to meet unique energy demands. While mitochondria are essential for synaptic transmission and synaptic plasticity, the mechanisms regulating mitochondria to support normal synapse function are incomple...

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Main Authors: Katy E. Pannoni, Quentin S. Fischer, Renesa Tarannum, Mikel L. Cawley, Mayd M. Alsalman, Nicole Acosta, Chisom Ezigbo, Daniela V. Gil, Logan A. Campbell, Shannon Farris
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Mitochondrial calcium uniporter
Hippocampal CA2
Synaptic plasticity
Mitochondria
Dendrites
Spines
Online Access:https://doi.org/10.1038/s41598-025-85958-4
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https://doi.org/10.1038/s41598-025-85958-4

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