AGS3-based optogenetic GDI induces GPCR-independent Gβγ signalling and macrophage migration

AGS3-based optogenetic GDI induces GPCR-independent Gβγ signalling and macrophage migration

G-protein-coupled receptors (GPCRs) are efficient guanine nucleotide exchange factors (GEFs) and exchange GDP to GTP on the Gα subunit of G-protein heterotrimers in response to various extracellular stimuli, including neurotransmitters and light. GPCRs primarily broadcast signals through activated G...

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Main Authors: Waruna Thotamune, Sithurandi Ubeysinghe, Chathuri Rajarathna, Dinesh Kankanamge, Koshala Olupothage, Aditya Chandu, Bryan A. Copits, Ajith Karunarathne
Format: Article
Language:English
Published: The Royal Society 2025-02-01
Series:Open Biology
Subjects:
GPCR
G proteins
GDI
optogenetics
macrophage migration
activators of G-protein signalling 3
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240181
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https://royalsocietypublishing.org/doi/10.1098/rsob.240181

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