Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis

Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis

Abstract Background Chronic cerebral hypoperfusion (CCH) is a pathophysiological hallmark of vascular dementia, the second most common form of dementia. CCH exerts complex and subtle detrimental effects on both the brain and peripheral systems. Irisin is a polypeptide primarily expressed in contract...

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Main Authors: Weiping Xiao, Yibing Yang, Lu Bai, Peixuan Yang, Runze Li, Daizhi Yang, Fanying Li, Lingzhi Quan, Qiupeng Liang, Yan Yan, Tiewei Qi, Feng Liang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Neuroinflammation
Subjects:
Chronic cerebral hypoperfusion
Irisin
Aerobic exercise
Neuronal apoptosis
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-025-03493-5
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