Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment
<b>Background/Objectives</b>: Multiple sclerosis (MS) is a disease characterized by demyelination and axonal damage of the central nervous system. Despite the observed benefits, highly effective treatment (HET)-based therapy has adverse effects, which include an increased risk of develop...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/12/12/2737 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850240127907921920 |
|---|---|
| author | Silvia García Adriana García-Martell Sandra Quiñones-Aguilar Sergio Sauri-Suárez Mario Antonio Téllez González Guillermo García-Castillo Juan Antonio Suárez-Cuenca Christian Gabriel Toledo-Lozano Paul Mondragón Terán Sofia Lizeth Alcaraz-Estrada |
| author_facet | Silvia García Adriana García-Martell Sandra Quiñones-Aguilar Sergio Sauri-Suárez Mario Antonio Téllez González Guillermo García-Castillo Juan Antonio Suárez-Cuenca Christian Gabriel Toledo-Lozano Paul Mondragón Terán Sofia Lizeth Alcaraz-Estrada |
| author_sort | Silvia García |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Multiple sclerosis (MS) is a disease characterized by demyelination and axonal damage of the central nervous system. Despite the observed benefits, highly effective treatment (HET)-based therapy has adverse effects, which include an increased risk of developing progressive multifocal leukoencephalopathy (PML). Additionally, the risk grows if the patient has antibodies for the John Cunningham virus (JCV). The appearance of PML is rare, and only one report has been found in Mexico. The objective of this research was to determine and analyze the immunological memory for JCV in a population of Mexican patients with MS under treatment. <b>Methods</b>: All participants underwent a complete medical history and neurological evaluation. Once they signed their informed consent, a blood sample was taken to determine if antibodies against JCV were present in their serum. <b>Results:</b> In total, 121 MS patients were analyzed, and the population consisted of 62.8% women and 37.2% men with an average age of 42.28. The three most common HETs received by the participants were natalizumab (67.76%), followed by teriflunomide and fingolimod. <b>Conclusions</b>: The seropositivity was 62.8%, and in this group, the average duration of disease evolution was 152.33 ± 93.37 months. Natalizumab was the most used HET, and despite this, only a positive association between a positive JCV antibody index with duration of fingolimod and history of depression was found. Also, a positive correlation of the JCV Ab index within the forms of SPMS and PPMS compared to RRMS was observed. No differences were observed between populations, type, and duration of MS. |
| format | Article |
| id | doaj-art-3543fe97b5ea49288967005e7d1d489b |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-3543fe97b5ea49288967005e7d1d489b2025-08-20T02:00:56ZengMDPI AGBiomedicines2227-90592024-11-011212273710.3390/biomedicines12122737Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under TreatmentSilvia García0Adriana García-Martell1Sandra Quiñones-Aguilar2Sergio Sauri-Suárez3Mario Antonio Téllez González4Guillermo García-Castillo5Juan Antonio Suárez-Cuenca6Christian Gabriel Toledo-Lozano7Paul Mondragón Terán8Sofia Lizeth Alcaraz-Estrada9Clinical Research Department, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, MexicoClinical Research Department, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, MexicoNeurology Department, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, MexicoNeurology Department, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, MexicoBiomedical Research Division, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, MexicoSpecial Testing Laboratory, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, MexicoClinical Research Department, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, MexicoClinical Research Department, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, MexicoCentro de Investigación en Ciencia Aplicada y Tecnología Avanzada Unidad Morelos, Instituto Polítecnico Nacional, Mexico City 03100, MexicoVirological Analysis and Reference Unit, National Medical Center “20 de Noviembre” Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City 03100, Mexico<b>Background/Objectives</b>: Multiple sclerosis (MS) is a disease characterized by demyelination and axonal damage of the central nervous system. Despite the observed benefits, highly effective treatment (HET)-based therapy has adverse effects, which include an increased risk of developing progressive multifocal leukoencephalopathy (PML). Additionally, the risk grows if the patient has antibodies for the John Cunningham virus (JCV). The appearance of PML is rare, and only one report has been found in Mexico. The objective of this research was to determine and analyze the immunological memory for JCV in a population of Mexican patients with MS under treatment. <b>Methods</b>: All participants underwent a complete medical history and neurological evaluation. Once they signed their informed consent, a blood sample was taken to determine if antibodies against JCV were present in their serum. <b>Results:</b> In total, 121 MS patients were analyzed, and the population consisted of 62.8% women and 37.2% men with an average age of 42.28. The three most common HETs received by the participants were natalizumab (67.76%), followed by teriflunomide and fingolimod. <b>Conclusions</b>: The seropositivity was 62.8%, and in this group, the average duration of disease evolution was 152.33 ± 93.37 months. Natalizumab was the most used HET, and despite this, only a positive association between a positive JCV antibody index with duration of fingolimod and history of depression was found. Also, a positive correlation of the JCV Ab index within the forms of SPMS and PPMS compared to RRMS was observed. No differences were observed between populations, type, and duration of MS.https://www.mdpi.com/2227-9059/12/12/2737multiple sclerosisJCVantibody indexHET |
| spellingShingle | Silvia García Adriana García-Martell Sandra Quiñones-Aguilar Sergio Sauri-Suárez Mario Antonio Téllez González Guillermo García-Castillo Juan Antonio Suárez-Cuenca Christian Gabriel Toledo-Lozano Paul Mondragón Terán Sofia Lizeth Alcaraz-Estrada Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment Biomedicines multiple sclerosis JCV antibody index HET |
| title | Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment |
| title_full | Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment |
| title_fullStr | Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment |
| title_full_unstemmed | Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment |
| title_short | Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment |
| title_sort | analysis of immunological memory for john cunningham virus in a mexican population of patients with multiple sclerosis under treatment |
| topic | multiple sclerosis JCV antibody index HET |
| url | https://www.mdpi.com/2227-9059/12/12/2737 |
| work_keys_str_mv | AT silviagarcia analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT adrianagarciamartell analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT sandraquinonesaguilar analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT sergiosaurisuarez analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT marioantoniotellezgonzalez analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT guillermogarciacastillo analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT juanantoniosuarezcuenca analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT christiangabrieltoledolozano analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT paulmondragonteran analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment AT sofializethalcarazestrada analysisofimmunologicalmemoryforjohncunninghamvirusinamexicanpopulationofpatientswithmultiplesclerosisundertreatment |