Exploratory GABAa-informed control network modulates hyperarousal brain dynamics in chronic insomnia

Exploratory GABAa-informed control network modulates hyperarousal brain dynamics in chronic insomnia

Abstract Chronic insomnia disorder is characterized by hyperarousal, a heightened cortical activation pattern that disrupts normal sleep. While hyperarousal has been linked to altered brain state dynamics, the underlying neurobiological mechanisms remain poorly understood, particularly regarding the...

Full description

Saved in:

Bibliographic Details
Main Authors:	Liyong Yu, Liang Gong, Xiaoqin Chen, Yuqi He, Rong Li, Xiaojuan Hong, Qi Zhang, Siyi Yu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-025-08439-4
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Progress in GABAA receptor agonists for insomnia disorder
by: Weiyi Wang, et al.
Published: (2024-11-01)

Aberrant Effective Connectivity Within and Between the Default Mode, Executive Control, and Salience Networks in Chronic Insomnia Disorder—Toward Identifying the Hyperarousal State
by: Todor Georgiev, et al.
Published: (2025-05-01)

Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder
by: Liyong Yu, et al.
Published: (2025-05-01)

The GABAA receptor RDL modulates the auditory sensitivity of malaria mosquitoes
by: David A. Ellis, et al.
Published: (2025-09-01)

Preclinical pharmacology of alogabat: a novel GABAA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABAA signaling
by: Giuseppe Cecere, et al.
Published: (2025-07-01)

Repeated activation of preoptic area recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional valence and hyperarousal states
by: Zhiping Cao, et al.
Published: (2025-04-01)

Posttraumatic Stress in Parents of Children Diagnosed with Cancer: Hyperarousal and Avoidance as Mediators of the Relationship between Re-Experiencing and Dysphoria.
by: Emma Hovén, et al.
Published: (2016-01-01)

Extrasynaptic α6 subunit-containing GABAA receptors modulate excitability in turtle spinal motoneurons.
by: Carmen Andres, et al.
Published: (2014-01-01)

Transcription of GABAA receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder
by: Louise Stiernman, et al.
Published: (2025-07-01)

Multiple functional neurosteroid binding sites on GABAA receptors.
by: Zi-Wei Chen, et al.
Published: (2019-03-01)

The Relationship between Urban Functional Structure and Insomnia: An Exploratory Analysis in Beijing, China
by: Sirui Chen, et al.
Published: (2024-09-01)

Spatial and Temporal Dynamics in the Ionic Driving Force for GABAA Receptors
by: R. Wright, et al.
Published: (2011-01-01)

GABAa receptori - molekulski supstrat za razvoj novih anksiolitika
by: Obradović Dragan I., et al.
Published: (2003-01-01)

GABA dysfunction in schizophrenia: The GABAA receptor as a potential therapeutic target
by: Brandon L.M. Crotchett, et al.
Published: (2025-06-01)

PET imaging of GABAA receptors in pancreatic islets by [11C]flumazenil
by: Faïza Maloum-Rami, et al.
Published: (2024-12-01)

Effect of Pranic Healing on sleep quality in primary insomnia: An exploratory study
by: G. N. Santhosh, et al.
Published: (2024-12-01)

Zhi-zi-chi decoction exerts hypnotic effect through gut-brain axis modulation in insomnia mice
by: Qianqian Wang, et al.
Published: (2025-08-01)

Cryo-EM structures of ρ1 GABAA receptors with antagonist and agonist drugs
by: Chen Fan, et al.
Published: (2025-08-01)

Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function
by: Valentina Licheri, et al.
Published: (2015-01-01)

Management of Chronic Insomnia : a guide for health professionals /
by: Ambrogetti ,Antonio
Published: (2011)

Management of chronic Insomnia : a guide for health professionals /
by: Ambrogetti, Antonio
Published: (2011)

A single main-chain hydrogen bond required to keep GABAA receptors closed
by: Cecilia M. Borghese, et al.
Published: (2025-07-01)

Altered GABAA receptor function in women with endometriosis: a possible pain‐related mechanism
by: Anton Sandström, et al.
Published: (2023-10-01)

Early developmental changes in GABAA receptor expression in nucleus accumbens medium spiny neurons
by: Ziyi (Zephyr) Wang, et al.
Published: (2024-12-01)

Chronic insomnia – beyond the symptom of insufficient sleep
by: Todor Georgiev, et al.
Published: (2025-05-01)

The Non-pharmacological treatment of chronic insomnia review
by: Aleksandra, et al.
Published: (2025-04-01)

Modulatory effect of various essential oils on different GABAA receptor subtypes present in the central nervous system
by: Christian Böhm, et al.
Published: (2025-08-01)

Insomnia in Pregnancy and Factors Related to Insomnia
by: Aynur Kızılırmak, et al.
Published: (2012-01-01)

Central amygdala somatostatin neurons modulate stress-induced sleep-onset insomnia
by: Wei Yao, et al.
Published: (2025-03-01)

Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
by: Carol Taylor-Burds, et al.
Published: (2015-01-01)

Follow-up multimodal changes on PET/MRI in fatal familial insomnia patient: a case report
by: Zhigeng Chen, et al.
Published: (2025-07-01)

DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel‐Induced Pain and Anxiety in Male Mice
by: Lixia Tian, et al.
Published: (2025-02-01)

The effect of stepwise acupuncture on cognition, insomnia, and tremors after traumatic brain injury: a case report
by: Ting-Yu Huang, et al.
Published: (2025-07-01)

Identification and quantification of GABAA R-α1-positive cells in the DCN of rats with behavioral evidence of noise-induced tinnitus
by: Xiaoping Du, et al.
Published: (2025-12-01)

Systemic corticosterone enhances fear memory extinction in rats: Involvement of the infralimbic medial prefrontal cortex GABAA and GABAB receptors
by: Samira Omoumi, et al.
Published: (2024-10-01)

Chronic Insomnia: Impact of Persistent Sleep Loss on Daytime Functioning
by: Marcus Hesse, et al.
Published: (2023-10-01)

Pharmacotherapy of insomnia in childhood
by: Z. G. Tadtaeva, et al.
Published: (2022-07-01)

Association of insomnia with suicide attempts in Chinese chronic schizophrenia patients with and without autistic symptoms
by: Wenzheng Li, et al.
Published: (2025-07-01)

Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis
by: Liang Gong, et al.
Published: (2019-01-01)

Efficacy of cognitive behavioral therapy for insomnia and lemborexant medication for different subtypes of chronic insomnia: study protocol for a randomized controlled trial
by: Si-Jing Chen, et al.
Published: (2025-05-01)