Gut Microbiota in HIV Infection: Implication for Disease Progression and Management
Survival rates among HIV patients have significantly improved since the introduction of antiretroviral therapy (ART) in HIV management. However, persistent disease progression and clinical complications in virally suppressed individuals point to additional contributing factors other than HIV replica...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/803185 |
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| _version_ | 1832552489486909440 |
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| author | Felix Chinweije Nwosu Ekaterina Avershina Robert Wilson Knut Rudi |
| author_facet | Felix Chinweije Nwosu Ekaterina Avershina Robert Wilson Knut Rudi |
| author_sort | Felix Chinweije Nwosu |
| collection | DOAJ |
| description | Survival rates among HIV patients have significantly improved since the introduction of antiretroviral therapy (ART) in HIV management. However, persistent disease progression and clinical complications in virally suppressed individuals point to additional contributing factors other than HIV replication; microbial translocation is one such factor. The role of underlying commensal microbes and microbial products that traverse the intestinal lumen into systemic circulation in the absence of overt bacteraemia is under current investigation. This review focuses on current knowledge of the complex microbial communities and microbial markers involved in the disruption of mucosal immune T-cells in the promotion of inflammatory processes in HIV infections. Unanswered questions and aims for future studies are addressed. We provide perspective for discussing potential future therapeutic strategies focused on modulating the gut microbiota to abate HIV disease progression. |
| format | Article |
| id | doaj-art-353966f05de542d090e83a6475e738cd |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-353966f05de542d090e83a6475e738cd2025-02-03T05:58:32ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/803185803185Gut Microbiota in HIV Infection: Implication for Disease Progression and ManagementFelix Chinweije Nwosu0Ekaterina Avershina1Robert Wilson2Knut Rudi3Hedmark University College, 2306 Hamar, NorwayDepartment of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, P.O. Box 5003, 1432 Aas, NorwayHedmark University College, 2306 Hamar, NorwayDepartment of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, P.O. Box 5003, 1432 Aas, NorwaySurvival rates among HIV patients have significantly improved since the introduction of antiretroviral therapy (ART) in HIV management. However, persistent disease progression and clinical complications in virally suppressed individuals point to additional contributing factors other than HIV replication; microbial translocation is one such factor. The role of underlying commensal microbes and microbial products that traverse the intestinal lumen into systemic circulation in the absence of overt bacteraemia is under current investigation. This review focuses on current knowledge of the complex microbial communities and microbial markers involved in the disruption of mucosal immune T-cells in the promotion of inflammatory processes in HIV infections. Unanswered questions and aims for future studies are addressed. We provide perspective for discussing potential future therapeutic strategies focused on modulating the gut microbiota to abate HIV disease progression.http://dx.doi.org/10.1155/2014/803185 |
| spellingShingle | Felix Chinweije Nwosu Ekaterina Avershina Robert Wilson Knut Rudi Gut Microbiota in HIV Infection: Implication for Disease Progression and Management Gastroenterology Research and Practice |
| title | Gut Microbiota in HIV Infection: Implication for Disease Progression and Management |
| title_full | Gut Microbiota in HIV Infection: Implication for Disease Progression and Management |
| title_fullStr | Gut Microbiota in HIV Infection: Implication for Disease Progression and Management |
| title_full_unstemmed | Gut Microbiota in HIV Infection: Implication for Disease Progression and Management |
| title_short | Gut Microbiota in HIV Infection: Implication for Disease Progression and Management |
| title_sort | gut microbiota in hiv infection implication for disease progression and management |
| url | http://dx.doi.org/10.1155/2014/803185 |
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