Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat
This study aimed to investigate any inflammatory effect of nicotine on rat embryo by exposing their mothers to different dosages of nicotine during pregnancy. During this experimental study, 32 pregnant healthy Wistar rats were divided into 4 equal groups, including a control and 3 nicotine exposure...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/274048 |
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| author | Yosouf Mohsenzadeh Asghar Rahmani Javad Cheraghi Maryam Pyrani Khairollah Asadollahi |
| author_facet | Yosouf Mohsenzadeh Asghar Rahmani Javad Cheraghi Maryam Pyrani Khairollah Asadollahi |
| author_sort | Yosouf Mohsenzadeh |
| collection | DOAJ |
| description | This study aimed to investigate any inflammatory effect of nicotine on rat embryo by exposing their mothers to different dosages of nicotine during pregnancy. During this experimental study, 32 pregnant healthy Wistar rats were divided into 4 equal groups, including a control and 3 nicotine exposure groups. Injections were performed subcutaneously starting at the first day of pregnancy until parturition. As the dosages of nicotine were increased, the weight gain by pregnant rats and the mean weight of their newborns were significantly reduced. Mean ± SD of hs-CRP was significantly higher among groups exposed to various dosages of nicotine (2, 4, and 6 mg/kg) compared to the control group (P<0.0001) and its increasing rate was also dose dependent. Mean ± SD serum level of IL-6 and TNF-α among all groups exposed to nicotine, except for 2 mg/kg nicotine injected group, was increased significantly (P<0.0001). Mean ± SD of serum level of TGF-β and nitrite oxide among exposure groups showed significant differences compared to the control group only at the dosage of 6 mg/kg (P<0.0001). The current study showed that exposing pregnant rats to nicotine causes a dose dependent increase in the rate of all the studied inflammatory serum markers among their newborns. |
| format | Article |
| id | doaj-art-3539588574314c4d83c302cccdfb25bd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3539588574314c4d83c302cccdfb25bd2025-02-03T05:59:21ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/274048274048Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn RatYosouf Mohsenzadeh0Asghar Rahmani1Javad Cheraghi2Maryam Pyrani3Khairollah Asadollahi4Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam 6931435647, IranStudent Researches Committee, Ilam University of Medical Sciences, Ilam 6931435647, IranDepartment of Physiology, Faculty of Veterinary, Ilam University, Ilam 6931435647, IranDepartment of Animal Physiology, Faculty of Veterinary, University of Tehran, Tehran 1419963111, IranDepartment of Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam 6931435647, IranThis study aimed to investigate any inflammatory effect of nicotine on rat embryo by exposing their mothers to different dosages of nicotine during pregnancy. During this experimental study, 32 pregnant healthy Wistar rats were divided into 4 equal groups, including a control and 3 nicotine exposure groups. Injections were performed subcutaneously starting at the first day of pregnancy until parturition. As the dosages of nicotine were increased, the weight gain by pregnant rats and the mean weight of their newborns were significantly reduced. Mean ± SD of hs-CRP was significantly higher among groups exposed to various dosages of nicotine (2, 4, and 6 mg/kg) compared to the control group (P<0.0001) and its increasing rate was also dose dependent. Mean ± SD serum level of IL-6 and TNF-α among all groups exposed to nicotine, except for 2 mg/kg nicotine injected group, was increased significantly (P<0.0001). Mean ± SD of serum level of TGF-β and nitrite oxide among exposure groups showed significant differences compared to the control group only at the dosage of 6 mg/kg (P<0.0001). The current study showed that exposing pregnant rats to nicotine causes a dose dependent increase in the rate of all the studied inflammatory serum markers among their newborns.http://dx.doi.org/10.1155/2014/274048 |
| spellingShingle | Yosouf Mohsenzadeh Asghar Rahmani Javad Cheraghi Maryam Pyrani Khairollah Asadollahi Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat Mediators of Inflammation |
| title | Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat |
| title_full | Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat |
| title_fullStr | Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat |
| title_full_unstemmed | Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat |
| title_short | Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat |
| title_sort | prenatal exposure to nicotine in pregnant rat increased inflammatory marker in newborn rat |
| url | http://dx.doi.org/10.1155/2014/274048 |
| work_keys_str_mv | AT yosoufmohsenzadeh prenatalexposuretonicotineinpregnantratincreasedinflammatorymarkerinnewbornrat AT asgharrahmani prenatalexposuretonicotineinpregnantratincreasedinflammatorymarkerinnewbornrat AT javadcheraghi prenatalexposuretonicotineinpregnantratincreasedinflammatorymarkerinnewbornrat AT maryampyrani prenatalexposuretonicotineinpregnantratincreasedinflammatorymarkerinnewbornrat AT khairollahasadollahi prenatalexposuretonicotineinpregnantratincreasedinflammatorymarkerinnewbornrat |