Exploring dihydropyrimidone derivatives as modulators of carbohydrate catabolic enzyme to mitigate diabetes

Exploring dihydropyrimidone derivatives as modulators of carbohydrate catabolic enzyme to mitigate diabetes

Abstract Diabetes is a prevalent and serious metabolic disorder affecting millions globally, and it poses extensive health risks due to elevated blood glucose levels. One promising approach for managing diabetes is the inhibition of α-glucosidase, an enzyme that plays a crucial role in carbohydrate...

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Main Authors: Syed Parween Ali, Farheen Mansoor, Shaymaa Fadhel Abbas Albaayit, Farman Ali, Ayed A. Dera, Muhammad Shahbaz, Jawad Ullah, Hailah M. Almohaimeed, Reem M. Gahtani, Ahmed M. Abdulfattah, Fahad M. Alshabrmi, Sarfaraz Alam, Saeed Ullah
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
α-Glucosidase inhibition
Non-cytotoxicity
Dihydropyrimidone
Diabetes therapy
Molecular docking simulation
Kinetics
Online Access:https://doi.org/10.1038/s41598-024-82765-1
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