Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot Study
Introduction 5-fluorouracil (5-FU) is a crucial agent in treating various types of cancer, particularly recurrent head and neck cancers (HNCs). According to prior studies, individuals who underwent therapeutic drug monitoring (TDM) based 5-FU dosage adjustments showed significantly higher...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2024-04-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1776294 |
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| author | P. Sharmila Nirojini N.K. Bhuvaneshwari N. Dharsshini S. Dhivya Bharathi K. Velavan |
| author_facet | P. Sharmila Nirojini N.K. Bhuvaneshwari N. Dharsshini S. Dhivya Bharathi K. Velavan |
| author_sort | P. Sharmila Nirojini |
| collection | DOAJ |
| description |
Introduction 5-fluorouracil (5-FU) is a crucial agent in treating various types of cancer, particularly recurrent head and neck cancers (HNCs). According to prior studies, individuals who underwent therapeutic drug monitoring (TDM) based 5-FU dosage adjustments showed significantly higher response rates and experienced fewer adverse events compared with those who received the standard 5-FU administration. This study aims to enhance our understanding of the overall clinical outcomes in patients with recurrent HNCs who received 500 mg of 5-FU through a pharmacokinetic (PK) analysis. |
| format | Article |
| id | doaj-art-3537d6f2c055471d845fc890f57e5f21 |
| institution | DOAJ |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-3537d6f2c055471d845fc890f57e5f212025-08-20T03:21:06ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292024-04-01450213414110.1055/s-0043-1776294Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot StudyP. Sharmila Nirojini0N.K. Bhuvaneshwari1N. Dharsshini2https://orcid.org/0000-0001-8728-068XS. Dhivya Bharathi3K. Velavan4Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy (Affiliated to the Dr. M.G.R. Medical University), Namakkal, Tamil Nadu, IndiaPharm D Intern, Swamy Vivekanandha College of Pharmacy (Affiliated to the Dr. M.G.R. Medical University), Namakkal, Tamil Nadu, IndiaPharm D Intern, Swamy Vivekanandha College of Pharmacy (Affiliated to the Dr. M.G.R. Medical University), Namakkal, Tamil Nadu, IndiaPharm D Intern, Swamy Vivekanandha College of Pharmacy (Affiliated to the Dr. M.G.R. Medical University), Namakkal, Tamil Nadu, IndiaRadiation Oncologist, Erode Cancer Centre, Erode, Tamil Nadu, India Introduction 5-fluorouracil (5-FU) is a crucial agent in treating various types of cancer, particularly recurrent head and neck cancers (HNCs). According to prior studies, individuals who underwent therapeutic drug monitoring (TDM) based 5-FU dosage adjustments showed significantly higher response rates and experienced fewer adverse events compared with those who received the standard 5-FU administration. This study aims to enhance our understanding of the overall clinical outcomes in patients with recurrent HNCs who received 500 mg of 5-FU through a pharmacokinetic (PK) analysis.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-17762945-fluorouraciltherapeutic drug monitoringhead and neck cancerdosage adjustments |
| spellingShingle | P. Sharmila Nirojini N.K. Bhuvaneshwari N. Dharsshini S. Dhivya Bharathi K. Velavan Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot Study Indian Journal of Medical and Paediatric Oncology 5-fluorouracil therapeutic drug monitoring head and neck cancer dosage adjustments |
| title | Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot Study |
| title_full | Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot Study |
| title_fullStr | Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot Study |
| title_full_unstemmed | Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot Study |
| title_short | Therapeutic Drug Monitoring of 5-Fluorouracil in Head and Neck Cancer Patients: An Interventional Pilot Study |
| title_sort | therapeutic drug monitoring of 5 fluorouracil in head and neck cancer patients an interventional pilot study |
| topic | 5-fluorouracil therapeutic drug monitoring head and neck cancer dosage adjustments |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1776294 |
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