Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer
This paper explores the multiple roles of oncostatin M (OSM) in the breast cancer microenvironment. OSM enhances invasion and metastasis of breast cancer cells by activating the JAK/STAT pathway, promoting epithelial-mesenchymal transition, cancer-associated fibroblast activation, and immune escape,...
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| Format: | Article |
| Language: | zho |
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Editorial Office of New Medicine
2025-03-01
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| Series: | Yixue xinzhi zazhi |
| Subjects: | |
| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2503/JnyptVSYqKfnwTbl2kVloqUfLLfcZ9eI2jshPrPH.pdf |
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| _version_ | 1850048222112776192 |
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| author | CHEN Wangcheng PANG Lili LAN Yuemei ZHANG Baihong |
| author_facet | CHEN Wangcheng PANG Lili LAN Yuemei ZHANG Baihong |
| author_sort | CHEN Wangcheng |
| collection | DOAJ |
| description | This paper explores the multiple roles of oncostatin M (OSM) in the breast cancer microenvironment. OSM enhances invasion and metastasis of breast cancer cells by activating the JAK/STAT pathway, promoting epithelial-mesenchymal transition, cancer-associated fibroblast activation, and immune escape, especially in bone and lung metastasis. OSM also works synergistically with matrix metalloproteinases to accelerate cancer progression. Although OSM is a potential therapeutic target, its pleiotropic nature presents a therapeutic challenge. Future studies are needed to develop more selective and safe OSM inhibitors, combined with other therapeutic strategies to improve efficacy. |
| format | Article |
| id | doaj-art-3534cab91add46ea83c859f0b1b5f1fd |
| institution | DOAJ |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-3534cab91add46ea83c859f0b1b5f1fd2025-08-20T02:54:01ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112025-03-0135333934410.12173/j.issn.1004-5511.2024110266619Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancerCHEN WangchengPANG LiliLAN YuemeiZHANG BaihongThis paper explores the multiple roles of oncostatin M (OSM) in the breast cancer microenvironment. OSM enhances invasion and metastasis of breast cancer cells by activating the JAK/STAT pathway, promoting epithelial-mesenchymal transition, cancer-associated fibroblast activation, and immune escape, especially in bone and lung metastasis. OSM also works synergistically with matrix metalloproteinases to accelerate cancer progression. Although OSM is a potential therapeutic target, its pleiotropic nature presents a therapeutic challenge. Future studies are needed to develop more selective and safe OSM inhibitors, combined with other therapeutic strategies to improve efficacy.https://yxxz.whuznhmedj.com/futureApi/storage/attach/2503/JnyptVSYqKfnwTbl2kVloqUfLLfcZ9eI2jshPrPH.pdfbreast canceroncostatin mtumor microenvironmenttumor metastasis |
| spellingShingle | CHEN Wangcheng PANG Lili LAN Yuemei ZHANG Baihong Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer Yixue xinzhi zazhi breast cancer oncostatin m tumor microenvironment tumor metastasis |
| title | Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer |
| title_full | Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer |
| title_fullStr | Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer |
| title_full_unstemmed | Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer |
| title_short | Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer |
| title_sort | mechanism of oncostatin m in microenvironment regulation and metastasis of breast cancer |
| topic | breast cancer oncostatin m tumor microenvironment tumor metastasis |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2503/JnyptVSYqKfnwTbl2kVloqUfLLfcZ9eI2jshPrPH.pdf |
| work_keys_str_mv | AT chenwangcheng mechanismofoncostatinminmicroenvironmentregulationandmetastasisofbreastcancer AT panglili mechanismofoncostatinminmicroenvironmentregulationandmetastasisofbreastcancer AT lanyuemei mechanismofoncostatinminmicroenvironmentregulationandmetastasisofbreastcancer AT zhangbaihong mechanismofoncostatinminmicroenvironmentregulationandmetastasisofbreastcancer |