Dietary Nicotinamide Mononucleotide, a Key NAD<sup>+</sup> Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in <i>db/db</i> Mice

Dietary Nicotinamide Mononucleotide, a Key NAD<sup>+</sup> Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in <i>db/db</i> Mice

<b>Background/Objectives</b>: Supplementation with nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD<sup>+</sup>) intermediate, exerts anti-aging, anti-obesity, and anti-diabetic effects in animal experiments. However, previous studies have evalu...

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Bibliographic Details
Main Authors: Bungo Shirouchi, Sarasa Mitsuta, Mina Higuchi, Mai Okumura, Kazunari Tanaka
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Metabolites
Subjects:
NMN
obesity
dyslipidemia
respiratory gas analysis
metabolic profile
hepatic fatty acid metabolism
Online Access:https://www.mdpi.com/2218-1989/15/5/333
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