The circadian clock coordinates ribosome biogenesis.
Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the ci...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001455&type=printable |
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| _version_ | 1849332458687823872 |
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| author | Céline Jouffe Gaspard Cretenet Laura Symul Eva Martin Florian Atger Felix Naef Frédéric Gachon |
| author_facet | Céline Jouffe Gaspard Cretenet Laura Symul Eva Martin Florian Atger Felix Naef Frédéric Gachon |
| author_sort | Céline Jouffe |
| collection | DOAJ |
| description | Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. Moreover, the circadian oscillator directly regulates the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis. |
| format | Article |
| id | doaj-art-3532aea0231449a6ae9ceb96b305ef92 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-3532aea0231449a6ae9ceb96b305ef922025-08-20T03:46:12ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852013-01-01111e100145510.1371/journal.pbio.1001455The circadian clock coordinates ribosome biogenesis.Céline JouffeGaspard CretenetLaura SymulEva MartinFlorian AtgerFelix NaefFrédéric GachonBiological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. Moreover, the circadian oscillator directly regulates the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001455&type=printable |
| spellingShingle | Céline Jouffe Gaspard Cretenet Laura Symul Eva Martin Florian Atger Felix Naef Frédéric Gachon The circadian clock coordinates ribosome biogenesis. PLoS Biology |
| title | The circadian clock coordinates ribosome biogenesis. |
| title_full | The circadian clock coordinates ribosome biogenesis. |
| title_fullStr | The circadian clock coordinates ribosome biogenesis. |
| title_full_unstemmed | The circadian clock coordinates ribosome biogenesis. |
| title_short | The circadian clock coordinates ribosome biogenesis. |
| title_sort | circadian clock coordinates ribosome biogenesis |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001455&type=printable |
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