Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome.

Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome.

Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the contribution of ADMA to the pathogenesis of impaired NO bioavailability and adve...

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Main Authors: Tsin W Yeo, Daniel A Lampah, Emiliana Tjitra, Retno Gitawati, Christabelle J Darcy, Catherine Jones, Enny Kenangalem, Yvette R McNeil, Donald L Granger, Bert K Lopansri, J Brice Weinberg, Ric N Price, Stephen B Duffull, David S Celermajer, Nicholas M Anstey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000868&type=printable
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