The identification of blood-derived response eQTLs reveals complex effects of regulatory variants on inflammatory and infectious disease risk.

The identification of blood-derived response eQTLs reveals complex effects of regulatory variants on inflammatory and infectious disease risk.

Hundreds of risk loci for immune mediated inflammatory and infectious diseases have been identified by genome-wide association studies (GWAS). Yet, what causal variants and genes in risk loci underpin the observed associations remains poorly understood for most. The identification of colocalized cis...

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Main Authors: Claire Liefferinckx, David Stern, Hélène Perée, Jérémie Bottieau, Alice Mayer, Christophe Dubussy, Eric Quertinmont, Vjola Tafciu, Charlotte Minsart, Vyacheslav Petrov, Alex Kvasz, Wouter Coppieters, Latifa Karim, Souad Rahmouni, Michel Georges, Denis Franchimont
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011599
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