Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on Resin
Abstract Peptide multifunctionalization is a crucial technique to develop peptide‐based agents for various purposes. Porphyrin‐peptide conjugates are a class of popular multifunctional peptides renowned for their multifunctional and multimodal properties. However, the tedious synthetic works for por...
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| Format: | Article |
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409771 |
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| author | Yue Wu Yuen‐Ting Wong Yik‐Hoi Yeung Pak‐Lun Lam Ho‐Fai Chau Wing‐Sze Tam Qian Zhang William C. S. Tai Ka‐Leung Wong |
| author_facet | Yue Wu Yuen‐Ting Wong Yik‐Hoi Yeung Pak‐Lun Lam Ho‐Fai Chau Wing‐Sze Tam Qian Zhang William C. S. Tai Ka‐Leung Wong |
| author_sort | Yue Wu |
| collection | DOAJ |
| description | Abstract Peptide multifunctionalization is a crucial technique to develop peptide‐based agents for various purposes. Porphyrin‐peptide conjugates are a class of popular multifunctional peptides renowned for their multifunctional and multimodal properties. However, the tedious synthetic works for porphyrin building blocks are involved in most previous studies. In this work, a modular solid‐phase synthetic approach is reported to construct trans‐AB2C porphyrin on peptide chains without presynthesized porphyrin building blocks. The products from this approach, which inherit both functionalities from the porphyrins and the modules employed for constructing porphyrins, show potential in biomedical and biomaterial applications. Furthermore, by extending this synthetic approach, the first example of “resin‐to‐resin” reaction is reported to link two peptides together along the construction of porphyrin motifs to give porphyrin‐peptide conjugates with two different peptide chains. |
| format | Article |
| id | doaj-art-3525b108bcb842e5806b2c96d7b07d60 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-3525b108bcb842e5806b2c96d7b07d602025-08-20T02:16:22ZengWileyAdvanced Science2198-38442025-04-011214n/an/a10.1002/advs.202409771Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on ResinYue Wu0Yuen‐Ting Wong1Yik‐Hoi Yeung2Pak‐Lun Lam3Ho‐Fai Chau4Wing‐Sze Tam5Qian Zhang6William C. S. Tai7Ka‐Leung Wong8Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd, Hung Hom Hong Kong SAR ChinaDepartment of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd, Hung Hom Hong Kong SAR ChinaDepartment of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd, Hung Hom Hong Kong SAR ChinaDepartment of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd, Hung Hom Hong Kong SAR ChinaDepartment of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd, Hung Hom Hong Kong SAR ChinaDepartment of Chemistry Hong Kong Baptist University 224 Waterloo Rd, Kowloon Tong Hong Kong SAR ChinaDepartment of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd, Hung Hom Hong Kong SAR ChinaDepartment of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd, Hung Hom Hong Kong SAR ChinaDepartment of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 11 Yuk Choi Rd, Hung Hom Hong Kong SAR ChinaAbstract Peptide multifunctionalization is a crucial technique to develop peptide‐based agents for various purposes. Porphyrin‐peptide conjugates are a class of popular multifunctional peptides renowned for their multifunctional and multimodal properties. However, the tedious synthetic works for porphyrin building blocks are involved in most previous studies. In this work, a modular solid‐phase synthetic approach is reported to construct trans‐AB2C porphyrin on peptide chains without presynthesized porphyrin building blocks. The products from this approach, which inherit both functionalities from the porphyrins and the modules employed for constructing porphyrins, show potential in biomedical and biomaterial applications. Furthermore, by extending this synthetic approach, the first example of “resin‐to‐resin” reaction is reported to link two peptides together along the construction of porphyrin motifs to give porphyrin‐peptide conjugates with two different peptide chains.https://doi.org/10.1002/advs.202409771multifunctional peptidepeptide ligationporphyrinporphyrin‐peptide conjugatessolid‐phase peptide synthesis |
| spellingShingle | Yue Wu Yuen‐Ting Wong Yik‐Hoi Yeung Pak‐Lun Lam Ho‐Fai Chau Wing‐Sze Tam Qian Zhang William C. S. Tai Ka‐Leung Wong Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on Resin Advanced Science multifunctional peptide peptide ligation porphyrin porphyrin‐peptide conjugates solid‐phase peptide synthesis |
| title | Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on Resin |
| title_full | Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on Resin |
| title_fullStr | Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on Resin |
| title_full_unstemmed | Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on Resin |
| title_short | Peptide Multifunctionalization via Modular Construction of Trans‐AB2C Porphyrin on Resin |
| title_sort | peptide multifunctionalization via modular construction of trans ab2c porphyrin on resin |
| topic | multifunctional peptide peptide ligation porphyrin porphyrin‐peptide conjugates solid‐phase peptide synthesis |
| url | https://doi.org/10.1002/advs.202409771 |
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