SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia

SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia

Abstract Inflammation aggravates secondary damage following spinal cord injury (SCI). M1 microglia induce inflammation and exert neurotoxic effects, whereas M2 microglia exert anti-inflammatory and neuroprotective effects. The sine oculis homeobox (SIX) gene family consists of six members, including...

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Bibliographic Details
Main Authors: Zhonghua Xu, Manhui Zhu, Hua Xie, Jiacheng Zhu, Hongming Zheng, Xiaojuan Liu, Yuting Zhang, Jinbo Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Sine oculis homeobox homolog 1 (SIX1)
Spinal cord injury (SCI)
Microglia
Polarization
Vascular endothelial growth factor-C (VEGF-C)
Online Access:https://doi.org/10.1038/s41598-024-82121-3
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