Effects of Explosion Shock Waves on Lung Injuries in Rabbits
The purpose of this study was to explore the damage effects and injury mechanism of free-field explosion shock waves on rabbit lungs. Six free-field explosion experiments, each with 500 g trinitrotoluene (TNT), were conducted as the shock wave overpressure acting on the rabbits was measured. The pea...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Shock and Vibration |
| Online Access: | http://dx.doi.org/10.1155/2021/6676244 |
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| author | Yanlong Sun Xinming Qian Chi-Min Shu Ziyuan Li Mengqi Yuan Qi Zhang Yanteng Li |
| author_facet | Yanlong Sun Xinming Qian Chi-Min Shu Ziyuan Li Mengqi Yuan Qi Zhang Yanteng Li |
| author_sort | Yanlong Sun |
| collection | DOAJ |
| description | The purpose of this study was to explore the damage effects and injury mechanism of free-field explosion shock waves on rabbit lungs. Six free-field explosion experiments, each with 500 g trinitrotoluene (TNT), were conducted as the shock wave overpressure acting on the rabbits was measured. The peak overpressure of the shock wave was 533, 390, 249, 102, and 69 kPa at the respective test points. Damage to the rabbit lungs caused by shock wave overpressure was investigated through observation, anatomical analysis, and hematoxylin-eosin (HE) staining processing. The shock wave overpressure of 69–102 kPa caused mild-to-moderate injury; the shock wave overpressure of 102–249 kPa caused moderate injury; the shock wave overpressure of 249–390 kPa resulted in moderate-to-severe injury; and the shock wave overpressure of 390–533 kPa caused severe injury to the rabbit. Mild, moderate, and severe injuries destroyed some, most, or all alveolar structures, correspondingly, as well as producing partial cell apoptosis. The overpressure damage mechanism primarily involves the collapse and rupture of pulmonary alveolus in the lung tissue. As a novel attempt, the investigation provided here may serve to improve the current shock wave injury mechanism. |
| format | Article |
| id | doaj-art-35188a0ff63b483fa586482f5fc2a02b |
| institution | Kabale University |
| issn | 1070-9622 1875-9203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Shock and Vibration |
| spelling | doaj-art-35188a0ff63b483fa586482f5fc2a02b2025-08-20T03:55:06ZengWileyShock and Vibration1070-96221875-92032021-01-01202110.1155/2021/66762446676244Effects of Explosion Shock Waves on Lung Injuries in RabbitsYanlong Sun0Xinming Qian1Chi-Min Shu2Ziyuan Li3Mengqi Yuan4Qi Zhang5Yanteng Li6State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, ChinaState Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, ChinaDepartment of Safety, Health, and Environmental Engineering, National Yunlin University of Science and Technology, Douliu, Yunlin, TaiwanState Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, ChinaState Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, ChinaState Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, ChinaDepartment of Neurosurgery, Navy General Hospital of PLA, Beijing, ChinaThe purpose of this study was to explore the damage effects and injury mechanism of free-field explosion shock waves on rabbit lungs. Six free-field explosion experiments, each with 500 g trinitrotoluene (TNT), were conducted as the shock wave overpressure acting on the rabbits was measured. The peak overpressure of the shock wave was 533, 390, 249, 102, and 69 kPa at the respective test points. Damage to the rabbit lungs caused by shock wave overpressure was investigated through observation, anatomical analysis, and hematoxylin-eosin (HE) staining processing. The shock wave overpressure of 69–102 kPa caused mild-to-moderate injury; the shock wave overpressure of 102–249 kPa caused moderate injury; the shock wave overpressure of 249–390 kPa resulted in moderate-to-severe injury; and the shock wave overpressure of 390–533 kPa caused severe injury to the rabbit. Mild, moderate, and severe injuries destroyed some, most, or all alveolar structures, correspondingly, as well as producing partial cell apoptosis. The overpressure damage mechanism primarily involves the collapse and rupture of pulmonary alveolus in the lung tissue. As a novel attempt, the investigation provided here may serve to improve the current shock wave injury mechanism.http://dx.doi.org/10.1155/2021/6676244 |
| spellingShingle | Yanlong Sun Xinming Qian Chi-Min Shu Ziyuan Li Mengqi Yuan Qi Zhang Yanteng Li Effects of Explosion Shock Waves on Lung Injuries in Rabbits Shock and Vibration |
| title | Effects of Explosion Shock Waves on Lung Injuries in Rabbits |
| title_full | Effects of Explosion Shock Waves on Lung Injuries in Rabbits |
| title_fullStr | Effects of Explosion Shock Waves on Lung Injuries in Rabbits |
| title_full_unstemmed | Effects of Explosion Shock Waves on Lung Injuries in Rabbits |
| title_short | Effects of Explosion Shock Waves on Lung Injuries in Rabbits |
| title_sort | effects of explosion shock waves on lung injuries in rabbits |
| url | http://dx.doi.org/10.1155/2021/6676244 |
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