Esophageal cancer associated with a sarcoid-like reaction and systemic sarcoidosis in lymph nodes: supportive findings of [18F]-fluorodeoxyglucose positron emission tomography–computed tomography during neoadjuvant therapy
Abstract Background In patients with esophageal cancer, differentiation between lymph node metastasis and lymphadenopathies from sarcoidosis or sarcoid-like reactions of lymph nodes is clinically important. Herein, we report two esophageal cancer cases with lymph node involvement of sarcoid-like rea...
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Japan Surgical Society
2018-06-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-018-0473-9 |
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| author | Takayoshi Kishino Keiichi Okano Yasuhisa Ando Hironobu Suto Eisuke Asano Minoru Oshima Masao Fujiwara Hisashi Usuki Hideki Kobara Tsutomu Masaki Emi Ibuki Yoshio Kushida Reiji Haba Yasuyuki Suzuki |
| author_facet | Takayoshi Kishino Keiichi Okano Yasuhisa Ando Hironobu Suto Eisuke Asano Minoru Oshima Masao Fujiwara Hisashi Usuki Hideki Kobara Tsutomu Masaki Emi Ibuki Yoshio Kushida Reiji Haba Yasuyuki Suzuki |
| author_sort | Takayoshi Kishino |
| collection | DOAJ |
| description | Abstract Background In patients with esophageal cancer, differentiation between lymph node metastasis and lymphadenopathies from sarcoidosis or sarcoid-like reactions of lymph nodes is clinically important. Herein, we report two esophageal cancer cases with lymph node involvement of sarcoid-like reaction or sarcoidosis. Case presentation One patient received chemotherapy and the other chemoradiotherapy as initial treatments. In both cases, [18F]-fluorodeoxyglucose positron emission tomography–computed tomography (FDG-PET/CT) was performed before and after chemo(radio)therapy. After the treatment, FDG uptake was not detected in the primary tumor, but it was slightly reduced in the hilar and mediastinal lymph nodes in both cases. These non-identical responses to chemo(radio)therapy suggest the presence of sarcoid-like reaction of lymph nodes associated with squamous cell carcinoma of the esophagus. Curative surgical resection was performed as treatment. Conclusions These FDG-PET/CT findings may be helpful to distinguish between metastasis and sarcoidosis-associated lymphadenopathy in esophageal cancer. |
| format | Article |
| id | doaj-art-3512e926d4804bdd863f0bfc41fa4080 |
| institution | OA Journals |
| issn | 2198-7793 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-3512e926d4804bdd863f0bfc41fa40802025-08-20T02:37:33ZengJapan Surgical SocietySurgical Case Reports2198-77932018-06-01411510.1186/s40792-018-0473-9Esophageal cancer associated with a sarcoid-like reaction and systemic sarcoidosis in lymph nodes: supportive findings of [18F]-fluorodeoxyglucose positron emission tomography–computed tomography during neoadjuvant therapyTakayoshi Kishino0Keiichi Okano1Yasuhisa Ando2Hironobu Suto3Eisuke Asano4Minoru Oshima5Masao Fujiwara6Hisashi Usuki7Hideki Kobara8Tsutomu Masaki9Emi Ibuki10Yoshio Kushida11Reiji Haba12Yasuyuki Suzuki13Department of Gastroenterological Surgery, Kagawa UniversityDepartment of Gastroenterological Surgery, Kagawa UniversityDepartment of Gastroenterological Surgery, Kagawa UniversityDepartment of Gastroenterological Surgery, Kagawa UniversityDepartment of Gastroenterological Surgery, Kagawa UniversityDepartment of Gastroenterological Surgery, Kagawa UniversityDepartment of Gastroenterological Surgery, Kagawa UniversityDepartment of Gastroenterological Surgery, Kagawa UniversityDepartment of Gastroenterology and Neurology, Kagawa UniversityDepartment of Gastroenterology and Neurology, Kagawa UniversityDepartment of Diagnostic Pathology, Kagawa UniversityDepartment of Diagnostic Pathology, Kagawa UniversityDepartment of Diagnostic Pathology, Kagawa UniversityDepartment of Gastroenterological Surgery, Kagawa UniversityAbstract Background In patients with esophageal cancer, differentiation between lymph node metastasis and lymphadenopathies from sarcoidosis or sarcoid-like reactions of lymph nodes is clinically important. Herein, we report two esophageal cancer cases with lymph node involvement of sarcoid-like reaction or sarcoidosis. Case presentation One patient received chemotherapy and the other chemoradiotherapy as initial treatments. In both cases, [18F]-fluorodeoxyglucose positron emission tomography–computed tomography (FDG-PET/CT) was performed before and after chemo(radio)therapy. After the treatment, FDG uptake was not detected in the primary tumor, but it was slightly reduced in the hilar and mediastinal lymph nodes in both cases. These non-identical responses to chemo(radio)therapy suggest the presence of sarcoid-like reaction of lymph nodes associated with squamous cell carcinoma of the esophagus. Curative surgical resection was performed as treatment. Conclusions These FDG-PET/CT findings may be helpful to distinguish between metastasis and sarcoidosis-associated lymphadenopathy in esophageal cancer.http://link.springer.com/article/10.1186/s40792-018-0473-9Esophageal squamous cell carcinomaSarcoidosisSarcoid-like reactionFDG-PETBilateral hilar lymphadenopathy |
| spellingShingle | Takayoshi Kishino Keiichi Okano Yasuhisa Ando Hironobu Suto Eisuke Asano Minoru Oshima Masao Fujiwara Hisashi Usuki Hideki Kobara Tsutomu Masaki Emi Ibuki Yoshio Kushida Reiji Haba Yasuyuki Suzuki Esophageal cancer associated with a sarcoid-like reaction and systemic sarcoidosis in lymph nodes: supportive findings of [18F]-fluorodeoxyglucose positron emission tomography–computed tomography during neoadjuvant therapy Surgical Case Reports Esophageal squamous cell carcinoma Sarcoidosis Sarcoid-like reaction FDG-PET Bilateral hilar lymphadenopathy |
| title | Esophageal cancer associated with a sarcoid-like reaction and systemic sarcoidosis in lymph nodes: supportive findings of [18F]-fluorodeoxyglucose positron emission tomography–computed tomography during neoadjuvant therapy |
| title_full | Esophageal cancer associated with a sarcoid-like reaction and systemic sarcoidosis in lymph nodes: supportive findings of [18F]-fluorodeoxyglucose positron emission tomography–computed tomography during neoadjuvant therapy |
| title_fullStr | Esophageal cancer associated with a sarcoid-like reaction and systemic sarcoidosis in lymph nodes: supportive findings of [18F]-fluorodeoxyglucose positron emission tomography–computed tomography during neoadjuvant therapy |
| title_full_unstemmed | Esophageal cancer associated with a sarcoid-like reaction and systemic sarcoidosis in lymph nodes: supportive findings of [18F]-fluorodeoxyglucose positron emission tomography–computed tomography during neoadjuvant therapy |
| title_short | Esophageal cancer associated with a sarcoid-like reaction and systemic sarcoidosis in lymph nodes: supportive findings of [18F]-fluorodeoxyglucose positron emission tomography–computed tomography during neoadjuvant therapy |
| title_sort | esophageal cancer associated with a sarcoid like reaction and systemic sarcoidosis in lymph nodes supportive findings of 18f fluorodeoxyglucose positron emission tomography computed tomography during neoadjuvant therapy |
| topic | Esophageal squamous cell carcinoma Sarcoidosis Sarcoid-like reaction FDG-PET Bilateral hilar lymphadenopathy |
| url | http://link.springer.com/article/10.1186/s40792-018-0473-9 |
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