Adult-onset Still’s disease during pregnancy: two case reports and a comprehensive literature review
BackgroundAdult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder marked by recurrent fever, rash, arthritis, and multi-organ involvement. Its occurrence with pregnancy complicates diagnosis and management.ObjectivesTo present the diagnosis and treatment process of two pregnant p...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1588300/full |
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| author | Wenchao Xu Wenchao Xu Wenchao Xu Shuang Huang Shuang Huang Shuang Huang Juanli Li Juanli Li Juanli Li Ting Li Ting Li Ting Li Yu Lu Yu Lu Yu Lu Liu Yang Liu Yang Liu Yang Jianyu Zhang Jianyu Zhang Jianyu Zhang Xue Li Xue Li Xue Li Jian Chen Jian Chen Jian Chen |
| author_facet | Wenchao Xu Wenchao Xu Wenchao Xu Shuang Huang Shuang Huang Shuang Huang Juanli Li Juanli Li Juanli Li Ting Li Ting Li Ting Li Yu Lu Yu Lu Yu Lu Liu Yang Liu Yang Liu Yang Jianyu Zhang Jianyu Zhang Jianyu Zhang Xue Li Xue Li Xue Li Jian Chen Jian Chen Jian Chen |
| author_sort | Wenchao Xu |
| collection | DOAJ |
| description | BackgroundAdult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder marked by recurrent fever, rash, arthritis, and multi-organ involvement. Its occurrence with pregnancy complicates diagnosis and management.ObjectivesTo present the diagnosis and treatment process of two pregnant patients with newly diagnosed AOSD.CasesTwo cases of AOSD were initially diagnosed during pregnancy. Case one involved a pregnant woman at 16 + 2 weeks of gestation with recurrent fevers, rash, and myalgia. She responded well to treatment with methylprednisolone and cyclosporine and subsequently had a normal vaginal delivery. Case two involved a pregnant woman at 30 + 6 weeks of gestation who presented with systemic joint pain and fever. After being diagnosed with AOSD, she underwent a cesarean section. Treatment included methylprednisolone, cyclosporine, and addition of methotrexate postpartum.ConclusionAdult-onset Still’s disease can be triggered by pregnancy, requiring a multidisciplinary approach for optimal management and fetal outcomes. |
| format | Article |
| id | doaj-art-350a3690df4d4fdd9bc12aa957b2d0cd |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-350a3690df4d4fdd9bc12aa957b2d0cd2025-08-20T03:17:24ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.15883001588300Adult-onset Still’s disease during pregnancy: two case reports and a comprehensive literature reviewWenchao Xu0Wenchao Xu1Wenchao Xu2Shuang Huang3Shuang Huang4Shuang Huang5Juanli Li6Juanli Li7Juanli Li8Ting Li9Ting Li10Ting Li11Yu Lu12Yu Lu13Yu Lu14Liu Yang15Liu Yang16Liu Yang17Jianyu Zhang18Jianyu Zhang19Jianyu Zhang20Xue Li21Xue Li22Xue Li23Jian Chen24Jian Chen25Jian Chen26Department of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, ChinaGuangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, ChinaBackgroundAdult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder marked by recurrent fever, rash, arthritis, and multi-organ involvement. Its occurrence with pregnancy complicates diagnosis and management.ObjectivesTo present the diagnosis and treatment process of two pregnant patients with newly diagnosed AOSD.CasesTwo cases of AOSD were initially diagnosed during pregnancy. Case one involved a pregnant woman at 16 + 2 weeks of gestation with recurrent fevers, rash, and myalgia. She responded well to treatment with methylprednisolone and cyclosporine and subsequently had a normal vaginal delivery. Case two involved a pregnant woman at 30 + 6 weeks of gestation who presented with systemic joint pain and fever. After being diagnosed with AOSD, she underwent a cesarean section. Treatment included methylprednisolone, cyclosporine, and addition of methotrexate postpartum.ConclusionAdult-onset Still’s disease can be triggered by pregnancy, requiring a multidisciplinary approach for optimal management and fetal outcomes.https://www.frontiersin.org/articles/10.3389/fmed.2025.1588300/fullpregnancy outcomesAdult-onset Still’s diseaseAOSDsafe medication useinflammatory disorder |
| spellingShingle | Wenchao Xu Wenchao Xu Wenchao Xu Shuang Huang Shuang Huang Shuang Huang Juanli Li Juanli Li Juanli Li Ting Li Ting Li Ting Li Yu Lu Yu Lu Yu Lu Liu Yang Liu Yang Liu Yang Jianyu Zhang Jianyu Zhang Jianyu Zhang Xue Li Xue Li Xue Li Jian Chen Jian Chen Jian Chen Adult-onset Still’s disease during pregnancy: two case reports and a comprehensive literature review Frontiers in Medicine pregnancy outcomes Adult-onset Still’s disease AOSD safe medication use inflammatory disorder |
| title | Adult-onset Still’s disease during pregnancy: two case reports and a comprehensive literature review |
| title_full | Adult-onset Still’s disease during pregnancy: two case reports and a comprehensive literature review |
| title_fullStr | Adult-onset Still’s disease during pregnancy: two case reports and a comprehensive literature review |
| title_full_unstemmed | Adult-onset Still’s disease during pregnancy: two case reports and a comprehensive literature review |
| title_short | Adult-onset Still’s disease during pregnancy: two case reports and a comprehensive literature review |
| title_sort | adult onset still s disease during pregnancy two case reports and a comprehensive literature review |
| topic | pregnancy outcomes Adult-onset Still’s disease AOSD safe medication use inflammatory disorder |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1588300/full |
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