An amplicon-based approach for full-genome characterization of HPV16

ABSTRACT Among the various genotypes of the human papillomavirus (HPV), the HPV16 genotype is the most oncogenic by far, and some (sub)lineages may be associated with an increased risk of cancer. Thus, characterizing the full genome is important to understand the link between the HPV16 genome variab...

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Main Authors: Isabelle Malet, Inès Draa, Valentin Leducq, Fanny Vuong, Pascale Bonnafous, Anne-Geneviève Marcelin, Vincent Calvez, Aude Jary
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
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Online Access:https://journals.asm.org/doi/10.1128/spectrum.03073-24
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author Isabelle Malet
Inès Draa
Valentin Leducq
Fanny Vuong
Pascale Bonnafous
Anne-Geneviève Marcelin
Vincent Calvez
Aude Jary
author_facet Isabelle Malet
Inès Draa
Valentin Leducq
Fanny Vuong
Pascale Bonnafous
Anne-Geneviève Marcelin
Vincent Calvez
Aude Jary
author_sort Isabelle Malet
collection DOAJ
description ABSTRACT Among the various genotypes of the human papillomavirus (HPV), the HPV16 genotype is the most oncogenic by far, and some (sub)lineages may be associated with an increased risk of cancer. Thus, characterizing the full genome is important to understand the link between the HPV16 genome variability and its transforming role. We set up a multiplex PCR approach combined with Oxford Nanopore Technologies for the HPV16 full-genome characterization. The primers were designed with PrimalScheme, and the optimization of the monoplex/multiplex PCR was performed on SiHa cells. After library preparation, the sequencing was performed on a GridION sequencing device to determine the sensitivity, the specificity, and the performance of the method. Fourteen primer pairs were selected to span the full genome. With the monoplex PCR, 12 primer pairs showed good amplification, while a double concentration of two primers was required to improve the amplification. We then performed a multiplex PCR approach by generating two pools comprising non-overlapping primer pairs. The multiplex PCR showed good sensitivity, allowing the amplification of HPV16 with a Ct value below 27 and providing a coverage greater than 99.9% and a sequencing depth greater than 100×. In addition, the specificity of the method was validated by the absence of amplification of other high-risk HPV genotypes compared with HPV16. We set up an amplicon-based approach to characterize the full genome and diversity of the HPV16 (sub)lineages. This approach shows good sensibility and specificity with limited cost, opening new perspectives in the field of whole-genome HPV sequencing.IMPORTANCEHPV16 is by far the most oncogenic genotype, so characterizing the genetic variability of its genome is important to better understand the link with its transforming role. We developed an amplicon-based approach combined with Oxford Nanopore Technologies next-generation sequencing to overlap the HPV16 genome, which is easy to implement in the laboratory and inexpensive in the field.
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spelling doaj-art-3508fb1cfb684bba8f4c7daa7814910e2025-08-20T03:28:22ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972025-07-0113710.1128/spectrum.03073-24An amplicon-based approach for full-genome characterization of HPV16Isabelle Malet0Inès Draa1Valentin Leducq2Fanny Vuong3Pascale Bonnafous4Anne-Geneviève Marcelin5Vincent Calvez6Aude Jary7Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique—Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Laboratoire de Virologie, Paris, Île-de-France, FranceSorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique—Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Laboratoire de Virologie, Paris, Île-de-France, FranceSorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique—Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Laboratoire de Virologie, Paris, Île-de-France, FranceSorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique—Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Laboratoire de Virologie, Paris, Île-de-France, FranceSorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique—Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Laboratoire de Virologie, Paris, Île-de-France, FranceSorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique—Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Laboratoire de Virologie, Paris, Île-de-France, FranceSorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique—Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Laboratoire de Virologie, Paris, Île-de-France, FranceSorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique—Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Pitié-Salpêtrière Charles-Foix, Laboratoire de Virologie, Paris, Île-de-France, FranceABSTRACT Among the various genotypes of the human papillomavirus (HPV), the HPV16 genotype is the most oncogenic by far, and some (sub)lineages may be associated with an increased risk of cancer. Thus, characterizing the full genome is important to understand the link between the HPV16 genome variability and its transforming role. We set up a multiplex PCR approach combined with Oxford Nanopore Technologies for the HPV16 full-genome characterization. The primers were designed with PrimalScheme, and the optimization of the monoplex/multiplex PCR was performed on SiHa cells. After library preparation, the sequencing was performed on a GridION sequencing device to determine the sensitivity, the specificity, and the performance of the method. Fourteen primer pairs were selected to span the full genome. With the monoplex PCR, 12 primer pairs showed good amplification, while a double concentration of two primers was required to improve the amplification. We then performed a multiplex PCR approach by generating two pools comprising non-overlapping primer pairs. The multiplex PCR showed good sensitivity, allowing the amplification of HPV16 with a Ct value below 27 and providing a coverage greater than 99.9% and a sequencing depth greater than 100×. In addition, the specificity of the method was validated by the absence of amplification of other high-risk HPV genotypes compared with HPV16. We set up an amplicon-based approach to characterize the full genome and diversity of the HPV16 (sub)lineages. This approach shows good sensibility and specificity with limited cost, opening new perspectives in the field of whole-genome HPV sequencing.IMPORTANCEHPV16 is by far the most oncogenic genotype, so characterizing the genetic variability of its genome is important to better understand the link with its transforming role. We developed an amplicon-based approach combined with Oxford Nanopore Technologies next-generation sequencing to overlap the HPV16 genome, which is easy to implement in the laboratory and inexpensive in the field.https://journals.asm.org/doi/10.1128/spectrum.03073-24HPV16full genomemultiplex PCRnext-generation sequencing
spellingShingle Isabelle Malet
Inès Draa
Valentin Leducq
Fanny Vuong
Pascale Bonnafous
Anne-Geneviève Marcelin
Vincent Calvez
Aude Jary
An amplicon-based approach for full-genome characterization of HPV16
Microbiology Spectrum
HPV16
full genome
multiplex PCR
next-generation sequencing
title An amplicon-based approach for full-genome characterization of HPV16
title_full An amplicon-based approach for full-genome characterization of HPV16
title_fullStr An amplicon-based approach for full-genome characterization of HPV16
title_full_unstemmed An amplicon-based approach for full-genome characterization of HPV16
title_short An amplicon-based approach for full-genome characterization of HPV16
title_sort amplicon based approach for full genome characterization of hpv16
topic HPV16
full genome
multiplex PCR
next-generation sequencing
url https://journals.asm.org/doi/10.1128/spectrum.03073-24
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