Immunotropic Properties of Anaferon and Anaferon Pediatric
Anaferon and pediatric anaferon based on release-active antibodies to interferon-γ (R-A antibodies to INF-γ) proved to be efficient in the treatment of many viral infections. Immunomodulating (immunotropic) properties of the drugs were revealed in the preclinical studies at many Russian and foreign...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/487 |
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| author | E. S. Zhavbert Yu. L. Dugina O. I. Epstein |
| author_facet | E. S. Zhavbert Yu. L. Dugina O. I. Epstein |
| author_sort | E. S. Zhavbert |
| collection | DOAJ |
| description | Anaferon and pediatric anaferon based on release-active antibodies to interferon-γ (R-A antibodies to INF-γ) proved to be efficient in the treatment of many viral infections. Immunomodulating (immunotropic) properties of the drugs were revealed in the preclinical studies at many Russian and foreign research medical institutions and are reviewed herein. Anaferon and pediatric anaferon stimulated the humoral and cellular immune responses and increased the neutrophil and macrophage activity. The crucial mechanism of the immunotropic action of R-A antibodies to INF-γ was the effect on the system of interferons and in particular on INF-γ and functionally conjugated cytokines, resulting in normalization of the functional activity of the innate factors of the immune defense and increasing of the antiviral action. The broad spectrum of the immunotropic activity provided the success of anaferon and anaferon pediatric for more than 10 years in the treatment and prophylaxis of the diseases associated with disorders in the immune system functional state. |
| format | Article |
| id | doaj-art-350888123c30487ca72caeb091c61a37 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-350888123c30487ca72caeb091c61a372025-08-20T03:20:37ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01585-61723486Immunotropic Properties of Anaferon and Anaferon PediatricE. S. Zhavbert0Yu. L. Dugina1O. I. Epstein2Materia Medica Holding, LtdMateria Medica Holding, LtdMateria Medica Holding, LtdAnaferon and pediatric anaferon based on release-active antibodies to interferon-γ (R-A antibodies to INF-γ) proved to be efficient in the treatment of many viral infections. Immunomodulating (immunotropic) properties of the drugs were revealed in the preclinical studies at many Russian and foreign research medical institutions and are reviewed herein. Anaferon and pediatric anaferon stimulated the humoral and cellular immune responses and increased the neutrophil and macrophage activity. The crucial mechanism of the immunotropic action of R-A antibodies to INF-γ was the effect on the system of interferons and in particular on INF-γ and functionally conjugated cytokines, resulting in normalization of the functional activity of the innate factors of the immune defense and increasing of the antiviral action. The broad spectrum of the immunotropic activity provided the success of anaferon and anaferon pediatric for more than 10 years in the treatment and prophylaxis of the diseases associated with disorders in the immune system functional state.https://www.antibiotics-chemotherapy.ru/jour/article/view/487anaferonpediatric anaferonrelease-active antibodies to inf-γimmunotropic activityimmunomodulatorsantivirals |
| spellingShingle | E. S. Zhavbert Yu. L. Dugina O. I. Epstein Immunotropic Properties of Anaferon and Anaferon Pediatric Антибиотики и Химиотерапия anaferon pediatric anaferon release-active antibodies to inf-γ immunotropic activity immunomodulators antivirals |
| title | Immunotropic Properties of Anaferon and Anaferon Pediatric |
| title_full | Immunotropic Properties of Anaferon and Anaferon Pediatric |
| title_fullStr | Immunotropic Properties of Anaferon and Anaferon Pediatric |
| title_full_unstemmed | Immunotropic Properties of Anaferon and Anaferon Pediatric |
| title_short | Immunotropic Properties of Anaferon and Anaferon Pediatric |
| title_sort | immunotropic properties of anaferon and anaferon pediatric |
| topic | anaferon pediatric anaferon release-active antibodies to inf-γ immunotropic activity immunomodulators antivirals |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/487 |
| work_keys_str_mv | AT eszhavbert immunotropicpropertiesofanaferonandanaferonpediatric AT yuldugina immunotropicpropertiesofanaferonandanaferonpediatric AT oiepstein immunotropicpropertiesofanaferonandanaferonpediatric |