Convergence of sepsis-associated encephalopathy pathogenesis onto microglia

Convergence of sepsis-associated encephalopathy pathogenesis onto microglia

Abstract Sepsis-associated encephalopathy (SAE) is a neurological dysfunction induced by sepsis, with symptoms ranging from mild delirium to deep coma. About 70% of patients with severe systemic infection develop SAE and with more than half of surviving patients suffering from long-term cognitive de...

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Bibliographic Details
Main Authors: Dan Xiao, Xiao Wang, Wanting Liang, Yunshu Yang, Yuting Du, Chunmao Liu, Feiyang Xu, Yang Yang, Mengying Wei, Guodong Yang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Sepsis-associated encephalopathy (SAE)
Neurological dysfunction
Neuroinflammation
Microglia activation
Glycometabolism
Lipid metabolism
Online Access:https://doi.org/10.1186/s12967-025-06635-8
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