Two sides of the coin: coagulation and inflammation in deep vein thrombosis – a prospective study on D-dimer and SIRI
BackgroundDeep vein thrombosis (DVT) is a major cause of morbidity and mortality, including pulmonary embolism and post-thrombotic syndrome. This study aimed to assess the effectiveness of inflammatory indices, derived from routine laboratory parameters, in predicting DVT.MethodIn this prospectively...
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Frontiers Media S.A.
2025-08-01
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| author | Ercan Kahraman Sirin Cetin Meryem Cetin Ayse Ulgen Ayse Ulgen |
| author_facet | Ercan Kahraman Sirin Cetin Meryem Cetin Ayse Ulgen Ayse Ulgen |
| author_sort | Ercan Kahraman |
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| description | BackgroundDeep vein thrombosis (DVT) is a major cause of morbidity and mortality, including pulmonary embolism and post-thrombotic syndrome. This study aimed to assess the effectiveness of inflammatory indices, derived from routine laboratory parameters, in predicting DVT.MethodIn this prospectively designed study, patients diagnosed with DVT through Doppler ultrasound at a tertiary healthcare center between December 2024 and February 2025, along with a control group confirmed to be DVT-free by Doppler ultrasound, were analyzed. Blood markers such as D-dimer, CRP, IL-6, and inflammatory indices (SIRI, MHR, PLR) were compared between groups. Statistical tests included chi-square, t-tests, logistic regression, and ROC curve analysis. Diagnostic performance was measured using odds ratios (ORs) with 95% confidence intervals (CIs).ResultInflammatory markers (SIRI, MHR, D-dimer, CRP, IL-6) were significantly elevated in DVT cases. SIRI demonstrated high diagnostic accuracy (AUC: 0.934) with a threshold of 0.97. Combined SIRI and D-dimer analyses yielded 93% positive and 100% negative predictive accuracy.ConclusionThis study demonstrated that inflammatory markers, particularly SIRI, were elevated in patients with deep vein thrombosis (DVT) and carried high predictive value in this patient group. The combined use of SIRI and D-dimer provided high diagnostic accuracy for DVT. SIRI, a low-cost index calculable through routine blood tests, was shown to be more effective than other inflammatory markers in predicting DVT. Additionally, the combination of SIRI and D-dimer yielded high positive and negative predictive values for DVT diagnosis. |
| format | Article |
| id | doaj-art-35062641012f4d3fac92dde6558b2df0 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-35062641012f4d3fac92dde6558b2df02025-08-20T03:59:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-08-011210.3389/fmed.2025.16042861604286Two sides of the coin: coagulation and inflammation in deep vein thrombosis – a prospective study on D-dimer and SIRIErcan Kahraman0Sirin Cetin1Meryem Cetin2Ayse Ulgen3Ayse Ulgen4Medical Faculty, Department of Cardiovascular Surgery, Amasya University, Amasya, TürkiyeMedical Faculty, Department of Biostatistics, Amasya University, Amasya, TürkiyeMedical Faculty, Department of Microbiology, Amasya University, Amasya, TürkiyeDepartment of Mathematics and Physics, School of Science and Technology, Nottingham Trent University, Nottingham, United KingdomDepartment of Biostatistics, Faculty of Medicine, Girne American University, Karmi, CyprusBackgroundDeep vein thrombosis (DVT) is a major cause of morbidity and mortality, including pulmonary embolism and post-thrombotic syndrome. This study aimed to assess the effectiveness of inflammatory indices, derived from routine laboratory parameters, in predicting DVT.MethodIn this prospectively designed study, patients diagnosed with DVT through Doppler ultrasound at a tertiary healthcare center between December 2024 and February 2025, along with a control group confirmed to be DVT-free by Doppler ultrasound, were analyzed. Blood markers such as D-dimer, CRP, IL-6, and inflammatory indices (SIRI, MHR, PLR) were compared between groups. Statistical tests included chi-square, t-tests, logistic regression, and ROC curve analysis. Diagnostic performance was measured using odds ratios (ORs) with 95% confidence intervals (CIs).ResultInflammatory markers (SIRI, MHR, D-dimer, CRP, IL-6) were significantly elevated in DVT cases. SIRI demonstrated high diagnostic accuracy (AUC: 0.934) with a threshold of 0.97. Combined SIRI and D-dimer analyses yielded 93% positive and 100% negative predictive accuracy.ConclusionThis study demonstrated that inflammatory markers, particularly SIRI, were elevated in patients with deep vein thrombosis (DVT) and carried high predictive value in this patient group. The combined use of SIRI and D-dimer provided high diagnostic accuracy for DVT. SIRI, a low-cost index calculable through routine blood tests, was shown to be more effective than other inflammatory markers in predicting DVT. Additionally, the combination of SIRI and D-dimer yielded high positive and negative predictive values for DVT diagnosis.https://www.frontiersin.org/articles/10.3389/fmed.2025.1604286/fullC-reactive proteinD-dimerdeep venous thrombosisInterleukin-6systemic inflammation response index (SIRI) |
| spellingShingle | Ercan Kahraman Sirin Cetin Meryem Cetin Ayse Ulgen Ayse Ulgen Two sides of the coin: coagulation and inflammation in deep vein thrombosis – a prospective study on D-dimer and SIRI Frontiers in Medicine C-reactive protein D-dimer deep venous thrombosis Interleukin-6 systemic inflammation response index (SIRI) |
| title | Two sides of the coin: coagulation and inflammation in deep vein thrombosis – a prospective study on D-dimer and SIRI |
| title_full | Two sides of the coin: coagulation and inflammation in deep vein thrombosis – a prospective study on D-dimer and SIRI |
| title_fullStr | Two sides of the coin: coagulation and inflammation in deep vein thrombosis – a prospective study on D-dimer and SIRI |
| title_full_unstemmed | Two sides of the coin: coagulation and inflammation in deep vein thrombosis – a prospective study on D-dimer and SIRI |
| title_short | Two sides of the coin: coagulation and inflammation in deep vein thrombosis – a prospective study on D-dimer and SIRI |
| title_sort | two sides of the coin coagulation and inflammation in deep vein thrombosis a prospective study on d dimer and siri |
| topic | C-reactive protein D-dimer deep venous thrombosis Interleukin-6 systemic inflammation response index (SIRI) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1604286/full |
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