Use of connectivity index and simple topological parameters for estimating the inhibition potency of acetylcholinesterase
Acetylcholinesterase (AChE) has proven to be an effective drug target in the treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and dementia. We developed a novel QSAR regression model for estimating potency to inhibit AChE, pKi, on a set of 75 structurally different compounds...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2022-04-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016422000391 |
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