Biomimetic magnetobacterial microrobots for active pneumonia therapy
Abstract Immense progress in synthetic micro-/nanorobots with diverse functionalities has been made for biomedical applications during the last decade. However, there is still a huge gap for miniature robots to realize efficient therapy from in vitro to in vivo level. Here click chemistry is used to...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-63231-6 |
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| author | Lishan Zhang Ze Chen Hui Ran Mirai Azechi Xue Yang Weichang Huang Hao Tian Lihan Shen Fei Peng Yingfeng Tu |
| author_facet | Lishan Zhang Ze Chen Hui Ran Mirai Azechi Xue Yang Weichang Huang Hao Tian Lihan Shen Fei Peng Yingfeng Tu |
| author_sort | Lishan Zhang |
| collection | DOAJ |
| description | Abstract Immense progress in synthetic micro-/nanorobots with diverse functionalities has been made for biomedical applications during the last decade. However, there is still a huge gap for miniature robots to realize efficient therapy from in vitro to in vivo level. Here click chemistry is used to introduce curcumin-loaded hybrid cell membrane nanoparticles to magnetotactic bacteria AMB-1 with magnetic actuation, thus creating biohybrid microrobots CurNPs@2TM-AMB-1 for active and efficient pneumonia therapy in vivo. In the presence of an external rotating magnetic field, the developed AR are capable of moving controllably and wirelessly, and efficiently scavenging inflammatory factors and SARS-CoV-2 pseudovirus due to the existing receptors from the cell membrane cloaking strategy, thereby inhibiting the virus invasion and reducing the damage of inflammation to the lungs. Due to the active movement, AR significantly increase and prolong the accumulation of Cur in the lungs in vivo, thus alleviating the pneumonia and regulating pneumonia microenvironment. The designed hybrid microrobot system, with magnetic actuation and active neutralization of inflammatory factors and virus, shows great promise as a potential platform for pneumonia therapy. |
| format | Article |
| id | doaj-art-35019b4d1b6e4baebc106613e0a06b0e |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-35019b4d1b6e4baebc106613e0a06b0e2025-08-24T11:36:37ZengNature PortfolioNature Communications2041-17232025-08-0116111510.1038/s41467-025-63231-6Biomimetic magnetobacterial microrobots for active pneumonia therapyLishan Zhang0Ze Chen1Hui Ran2Mirai Azechi3Xue Yang4Weichang Huang5Hao Tian6Lihan Shen7Fei Peng8Yingfeng Tu9NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical UniversityGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of SciencesNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical UniversityNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical UniversityNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical UniversityNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical UniversityNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical UniversityDepartment of Critical Care Medicine, Dongguan Institute of Respiratory and Critical Care Medicine, Affiliated Dongguan Hospital, Southern Medical UniversitySchool of Materials Science and Engineering, Sun Yat-Sen UniversityNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical UniversityAbstract Immense progress in synthetic micro-/nanorobots with diverse functionalities has been made for biomedical applications during the last decade. However, there is still a huge gap for miniature robots to realize efficient therapy from in vitro to in vivo level. Here click chemistry is used to introduce curcumin-loaded hybrid cell membrane nanoparticles to magnetotactic bacteria AMB-1 with magnetic actuation, thus creating biohybrid microrobots CurNPs@2TM-AMB-1 for active and efficient pneumonia therapy in vivo. In the presence of an external rotating magnetic field, the developed AR are capable of moving controllably and wirelessly, and efficiently scavenging inflammatory factors and SARS-CoV-2 pseudovirus due to the existing receptors from the cell membrane cloaking strategy, thereby inhibiting the virus invasion and reducing the damage of inflammation to the lungs. Due to the active movement, AR significantly increase and prolong the accumulation of Cur in the lungs in vivo, thus alleviating the pneumonia and regulating pneumonia microenvironment. The designed hybrid microrobot system, with magnetic actuation and active neutralization of inflammatory factors and virus, shows great promise as a potential platform for pneumonia therapy.https://doi.org/10.1038/s41467-025-63231-6 |
| spellingShingle | Lishan Zhang Ze Chen Hui Ran Mirai Azechi Xue Yang Weichang Huang Hao Tian Lihan Shen Fei Peng Yingfeng Tu Biomimetic magnetobacterial microrobots for active pneumonia therapy Nature Communications |
| title | Biomimetic magnetobacterial microrobots for active pneumonia therapy |
| title_full | Biomimetic magnetobacterial microrobots for active pneumonia therapy |
| title_fullStr | Biomimetic magnetobacterial microrobots for active pneumonia therapy |
| title_full_unstemmed | Biomimetic magnetobacterial microrobots for active pneumonia therapy |
| title_short | Biomimetic magnetobacterial microrobots for active pneumonia therapy |
| title_sort | biomimetic magnetobacterial microrobots for active pneumonia therapy |
| url | https://doi.org/10.1038/s41467-025-63231-6 |
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