The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses
Background: : Preventing or reducing the risk of cognitive decline and dementia is of great public health interest. Longitudinal data from diverse samples are needed to properly inform clinicians, researchers, and policy makers. CAN-PROTECT is a recently launched online observational cohort study th...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Aging and Health Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667032124000283 |
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| author | Zahinoor Ismail Dylan X. Guan Daniella Vellone Clive Ballard Byron Creese Anne Corbett Ellie Pickering Adam Bloomfield Adam Hampshire Ramnik Sekhon Pamela Roach Eric E. Smith |
| author_facet | Zahinoor Ismail Dylan X. Guan Daniella Vellone Clive Ballard Byron Creese Anne Corbett Ellie Pickering Adam Bloomfield Adam Hampshire Ramnik Sekhon Pamela Roach Eric E. Smith |
| author_sort | Zahinoor Ismail |
| collection | DOAJ |
| description | Background: : Preventing or reducing the risk of cognitive decline and dementia is of great public health interest. Longitudinal data from diverse samples are needed to properly inform clinicians, researchers, and policy makers. CAN-PROTECT is a recently launched online observational cohort study that assesses factors contributing to both risk for incident cognitive decline and dementia and resilience against brain aging, in participants across the lifespan. Methods: : Measures of cognition, behaviour, and quality of life administered to both participants and study partners were compared using partial Spearman correlations adjusted for participant and study partner age, sex, and education. In participants, relationships between cognition, behaviour, function, and quality of life were examined using adjusted multivariable linear and negative binomial regression models. Results: : In the first three-month window, 2150 participants spanning all Canadian provinces enrolled; 637 nominated study partners had already completed assessments. Engagement with the study was excellent, with many optional assessments completed. Initial analyses demonstrated relationships between cognition, behaviour, function, and quality of life. Discussion: : These preliminary results speak to the utility and feasibility of CAN-PROTECT to obtain data relevant to brain health, highlighting the public interest in participating in studies on cognition. The online portal facilitated participation of a geographically diverse sample. This group is ideal to study brain aging, dementia prevention, and early detection of neurodegenerative disease. Longitudinal data will provide additional insights. Several features of CAN-PROTECT are important to consider in terms of assessing risk and resilience in Canadians, and for further development and recruitment of a research-ready cohort. |
| format | Article |
| id | doaj-art-34fe00bdf3dd44f88aa6c856806521c0 |
| institution | OA Journals |
| issn | 2667-0321 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging and Health Research |
| spelling | doaj-art-34fe00bdf3dd44f88aa6c856806521c02025-08-20T01:54:16ZengElsevierAging and Health Research2667-03212024-12-014410020710.1016/j.ahr.2024.100207The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analysesZahinoor Ismail0Dylan X. Guan1Daniella Vellone2Clive Ballard3Byron Creese4Anne Corbett5Ellie Pickering6Adam Bloomfield7Adam Hampshire8Ramnik Sekhon9Pamela Roach10Eric E. Smith11Cumming School of Medicine, University of Calgary, Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Canada; Department of Psychiatry, University of Calgary, Calgary, Canada; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada; Department of Clinical Neurosciences, University of Calgary, Calgary, Canada; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK; Corresponding author.Cumming School of Medicine, University of Calgary, Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, CanadaClinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UKDepartment of Psychiatry, College of Health Medicine and Life Sciences, Brunel University London, London, UKClinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UKClinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UKClinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKHotchkiss Brain Institute, University of Calgary, Calgary, CanadaCumming School of Medicine, University of Calgary, Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Canada; Department of Family Medicine, University of Calgary, Calgary, CanadaCumming School of Medicine, University of Calgary, Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Canada; Department of Clinical Neurosciences, University of Calgary, Calgary, CanadaBackground: : Preventing or reducing the risk of cognitive decline and dementia is of great public health interest. Longitudinal data from diverse samples are needed to properly inform clinicians, researchers, and policy makers. CAN-PROTECT is a recently launched online observational cohort study that assesses factors contributing to both risk for incident cognitive decline and dementia and resilience against brain aging, in participants across the lifespan. Methods: : Measures of cognition, behaviour, and quality of life administered to both participants and study partners were compared using partial Spearman correlations adjusted for participant and study partner age, sex, and education. In participants, relationships between cognition, behaviour, function, and quality of life were examined using adjusted multivariable linear and negative binomial regression models. Results: : In the first three-month window, 2150 participants spanning all Canadian provinces enrolled; 637 nominated study partners had already completed assessments. Engagement with the study was excellent, with many optional assessments completed. Initial analyses demonstrated relationships between cognition, behaviour, function, and quality of life. Discussion: : These preliminary results speak to the utility and feasibility of CAN-PROTECT to obtain data relevant to brain health, highlighting the public interest in participating in studies on cognition. The online portal facilitated participation of a geographically diverse sample. This group is ideal to study brain aging, dementia prevention, and early detection of neurodegenerative disease. Longitudinal data will provide additional insights. Several features of CAN-PROTECT are important to consider in terms of assessing risk and resilience in Canadians, and for further development and recruitment of a research-ready cohort.http://www.sciencedirect.com/science/article/pii/S2667032124000283Online cohort studyBrain agingDementiaRisk factorsCognitive reserveCognitive decline |
| spellingShingle | Zahinoor Ismail Dylan X. Guan Daniella Vellone Clive Ballard Byron Creese Anne Corbett Ellie Pickering Adam Bloomfield Adam Hampshire Ramnik Sekhon Pamela Roach Eric E. Smith The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses Aging and Health Research Online cohort study Brain aging Dementia Risk factors Cognitive reserve Cognitive decline |
| title | The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses |
| title_full | The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses |
| title_fullStr | The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses |
| title_full_unstemmed | The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses |
| title_short | The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses |
| title_sort | canadian platform for research online to investigate health quality of life cognition behaviour function and caregiving in aging can protect study protocol platform description and preliminary analyses |
| topic | Online cohort study Brain aging Dementia Risk factors Cognitive reserve Cognitive decline |
| url | http://www.sciencedirect.com/science/article/pii/S2667032124000283 |
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