Optimizing predictive accuracy of the two-component repair model for pediatric TBI: Pediatric-specific parameters, toxicity endpoint harmonization, and dose-rate safeguards
In response to the innovative two-component repair model for pediatric TBI renal toxicity prediction, this letter proposes three key refinements to enhance clinical translation: adopting pediatric-specific radiobiological parameters (e.g., DNA-PKcs dynamics, α/β ratios) to address systematic overest...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Clinical and Translational Radiation Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630825000965 |
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| _version_ | 1849406888459894784 |
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| author | Ruijie Meng |
| author_facet | Ruijie Meng |
| author_sort | Ruijie Meng |
| collection | DOAJ |
| description | In response to the innovative two-component repair model for pediatric TBI renal toxicity prediction, this letter proposes three key refinements to enhance clinical translation: adopting pediatric-specific radiobiological parameters (e.g., DNA-PKcs dynamics, α/β ratios) to address systematic overestimation of radiation tolerance; harmonizing toxicity endpoints to CTCAE v5.0 ≥Grade 3 criteria to strengthen doseresponse associations and enable precise risk stratification; and implementing institution-specific minimum dose-rate thresholds to mitigate unmodeled vascular susceptibility during low-dose-rate TBI. Collectively, these optimizations will improve predictive accuracy and support personalized radiotherapy for high-risk pediatric cohorts. |
| format | Article |
| id | doaj-art-34fb8056b04941569dcd9b8cff69ea18 |
| institution | Kabale University |
| issn | 2405-6308 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj-art-34fb8056b04941569dcd9b8cff69ea182025-08-20T03:36:14ZengElsevierClinical and Translational Radiation Oncology2405-63082025-09-015410100410.1016/j.ctro.2025.101004Optimizing predictive accuracy of the two-component repair model for pediatric TBI: Pediatric-specific parameters, toxicity endpoint harmonization, and dose-rate safeguardsRuijie Meng0Address: Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an, Shaanxi Province 710061, PR China.; Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, PR ChinaIn response to the innovative two-component repair model for pediatric TBI renal toxicity prediction, this letter proposes three key refinements to enhance clinical translation: adopting pediatric-specific radiobiological parameters (e.g., DNA-PKcs dynamics, α/β ratios) to address systematic overestimation of radiation tolerance; harmonizing toxicity endpoints to CTCAE v5.0 ≥Grade 3 criteria to strengthen doseresponse associations and enable precise risk stratification; and implementing institution-specific minimum dose-rate thresholds to mitigate unmodeled vascular susceptibility during low-dose-rate TBI. Collectively, these optimizations will improve predictive accuracy and support personalized radiotherapy for high-risk pediatric cohorts.http://www.sciencedirect.com/science/article/pii/S2405630825000965Pediatric TBIRenal toxicityRadiation tolerance predictionDose-rate effectsPrecision radiotherapy |
| spellingShingle | Ruijie Meng Optimizing predictive accuracy of the two-component repair model for pediatric TBI: Pediatric-specific parameters, toxicity endpoint harmonization, and dose-rate safeguards Clinical and Translational Radiation Oncology Pediatric TBI Renal toxicity Radiation tolerance prediction Dose-rate effects Precision radiotherapy |
| title | Optimizing predictive accuracy of the two-component repair model for pediatric TBI: Pediatric-specific parameters, toxicity endpoint harmonization, and dose-rate safeguards |
| title_full | Optimizing predictive accuracy of the two-component repair model for pediatric TBI: Pediatric-specific parameters, toxicity endpoint harmonization, and dose-rate safeguards |
| title_fullStr | Optimizing predictive accuracy of the two-component repair model for pediatric TBI: Pediatric-specific parameters, toxicity endpoint harmonization, and dose-rate safeguards |
| title_full_unstemmed | Optimizing predictive accuracy of the two-component repair model for pediatric TBI: Pediatric-specific parameters, toxicity endpoint harmonization, and dose-rate safeguards |
| title_short | Optimizing predictive accuracy of the two-component repair model for pediatric TBI: Pediatric-specific parameters, toxicity endpoint harmonization, and dose-rate safeguards |
| title_sort | optimizing predictive accuracy of the two component repair model for pediatric tbi pediatric specific parameters toxicity endpoint harmonization and dose rate safeguards |
| topic | Pediatric TBI Renal toxicity Radiation tolerance prediction Dose-rate effects Precision radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405630825000965 |
| work_keys_str_mv | AT ruijiemeng optimizingpredictiveaccuracyofthetwocomponentrepairmodelforpediatrictbipediatricspecificparameterstoxicityendpointharmonizationanddoseratesafeguards |